The risk of immune thrombocytopenic purpura after vaccination in children and adolescents

• Published in: Pediatrics (Evanston) Vol. 129; no. 2; p. 248
• Main Authors: O'Leary, Sean T, Glanz, Jason M, McClure, David L, Akhtar, Aysha, Daley, Matthew F, Nakasato, Cynthia, Baxter, Roger, Davis, Robert L, Izurieta, Hector S, Lieu, Tracy A, Ball, Robert
• Format: Journal Article
• Language: English
• Published: United States 01.02.2012
• Subjects: Adolescent; Chickenpox Vaccine - adverse effects; Chickenpox Vaccine - immunology; Child; Child, Preschool; Cohort Studies; Diphtheria-Tetanus-acellular Pertussis Vaccines - adverse effects; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology; Female; Hepatitis A Vaccines - adverse effects; Hepatitis A Vaccines - immunology; Humans; Infant; Male; Purpura, Thrombocytopenic, Idiopathic - epidemiology; Purpura, Thrombocytopenic, Idiopathic - etiology; Retrospective Studies; Risk; United States; Vaccination - adverse effects; United States

The risk of immune thrombocytopenic purpura (ITP) after childhood vaccines other than measles-mumps-rubella vaccine (MMR) is unknown. Using data from 5 managed care organizations for 2000 to 2009, we identified a cohort of 1.8 million children ages 6 weeks to 17 years. Potential ITP cases were ident...