Is there a linear relationship between the dose of ruminant trans-fatty acids and cardiovascular risk markers in healthy subjects: results from a systematic review and meta-regression of randomised clinical trials

• Published in: British journal of nutrition Vol. 112; no. 12; pp. 1914 - 1922
• Main Authors: Gayet-Boyer, Constance, Tenenhaus-Aziza, Fanny, Prunet, Caroline, Marmonier, Corinne, Malpuech-Brugère, Corinne, Lamarche, Benoit, Chardigny, Jean-Michel
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.12.2014; Cambridge University Press (CUP)
• Subjects: adverse effects; Animals; Atherosclerosis; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Cholesterol; Cholesterol - blood; Clinical trials; Cohort analysis; Dairy products; Diet; Dietary Fats - adverse effects; energy intake; Fatty acids; Food and Nutrition; Health risks; High density lipoprotein; high density lipoprotein cholesterol; Humans; Life Sciences; Lipids; Low density lipoprotein; low density lipoprotein cholesterol; people; Ratios; Regression analysis; Risk factors; Ruminants; Systematic review; Systematic Review with Meta-Analysis; Trans fats; trans fatty acids; Trans Fatty Acids - administration & dosage; Trans Fatty Acids - adverse effects; Cardiovascular markers; Systematic review; Ruminant trans-fats; Randomised clinical trials

The effects of ruminant (R) trans-fatty acids (TFA) on the risk of CVD are still under debate. It could be argued that the lack of the effect of R-TFA may be the result of the small amount of their intake. Taking into consideration the growing available data from intervention studies, we carried out...