Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery
Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40 mole/mole). Thes...
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| Published in | International journal of pharmaceutics Vol. 358; no. 1; pp. 263 - 270 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
24.06.2008
Elsevier |
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| Online Access | Get full text |
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| Abstract | Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40
mole/mole). These cationic MPs were then combined with polyethylenimine (PEI) condensed plasmid DNA, followed by transferrin. The resulting magnetic electrostatic complexes retained relatively compact particle size and showed complete DNA condensation. Their transfection activity in the presence of a static magnetic field was evaluated by luciferase and green fluorescent protein (GFP) reporter genes. The magnetic complexes exhibited up to 300-fold higher transfection activity compared to commonly used cationic liposomes or cationic polymer complexes, based on luciferase assay. The enhancement in transfection activity was maximized when the cells were exposed to the vectors for a relatively short period of time (15
min), or were treated in media containing 10% serum. Incorporation of transferrin further improved transfection efficiency of the cationic MPs. However, when cells were incubated for 4
h in serum-free media, magnetic and non-magnetic vectors showed similar transfection efficiencies. In conclusion, transferrin-associated cationic MPs are excellent gene transfer vectors that can mediate very rapid and efficient gene transfer
in vitro in the presence of a magnetic field. |
|---|---|
| AbstractList | Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40 mole/mole). These cationic MPs were then combined with polyethylenimine (PEI) condensed plasmid DNA, followed by transferrin. The resulting magnetic electrostatic complexes retained relatively compact particle size and showed complete DNA condensation. Their transfection activity in the presence of a static magnetic field was evaluated by luciferase and green fluorescent protein (GFP) reporter genes. The magnetic complexes exhibited up to 300-fold higher transfection activity compared to commonly used cationic liposomes or cationic polymer complexes, based on luciferase assay. The enhancement in transfection activity was maximized when the cells were exposed to the vectors for a relatively short period of time (15 min), or were treated in media containing 10% serum. Incorporation of transferrin further improved transfection efficiency of the cationic MPs. However, when cells were incubated for 4 h in serum-free media, magnetic and non-magnetic vectors showed similar transfection efficiencies. In conclusion, transferrin-associated cationic MPs are excellent gene transfer vectors that can mediate very rapid and efficient gene transfer
in vitro
in the presence of a magnetic field. Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40 mole/mole). These cationic MPs were then combined with polyethylenimine (PEI) condensed plasmid DNA, followed by transferrin. The resulting magnetic electrostatic complexes retained relatively compact particle size and showed complete DNA condensation. Their transfection activity in the presence of a static magnetic field was evaluated by luciferase and green fluorescent protein (GFP) reporter genes. The magnetic complexes exhibited up to 300-fold higher transfection activity compared to commonly used cationic liposomes or cationic polymer complexes, based on luciferase assay. The enhancement in transfection activity was maximized when the cells were exposed to the vectors for a relatively short period of time (15 min), or were treated in media containing 10% serum. Incorporation of transferrin further improved transfection efficiency of the cationic MPs. However, when cells were incubated for 4 h in serum-free media, magnetic and non-magnetic vectors showed similar transfection efficiencies. In conclusion, transferrin-associated cationic MPs are excellent gene transfer vectors that can mediate very rapid and efficient gene transfer in vitro in the presence of a magnetic field. Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40 mole/mole). These cationic MPs were then combined with polyethylenimine (PEI) condensed plasmid DNA, followed by transferrin. The resulting magnetic electrostatic complexes retained relatively compact particle size and showed complete DNA condensation. Their transfection activity in the presence of a static magnetic field was evaluated by luciferase and green fluorescent protein (GFP) reporter genes. The magnetic complexes exhibited up to 300-fold higher transfection activity compared to commonly used cationic liposomes or cationic polymer complexes, based on luciferase assay. The enhancement in transfection activity was maximized when the cells were exposed to the vectors for a relatively short period of time (15 min), or were treated in media containing 10% serum. Incorporation of transferrin further improved transfection efficiency of the cationic MPs. However, when cells were incubated for 4h in serum-free media, magnetic and non-magnetic vectors showed similar transfection efficiencies. In conclusion, transferrin-associated cationic MPs are excellent gene transfer vectors that can mediate very rapid and efficient gene transfer in vitro in the presence of a magnetic field. |
| Author | Lee, Robert J. Lee, L. James Guan, Jingjiao Yoo, Jung-Woo Epstein, Arthur J. Pan, Xiaogang |
| AuthorAffiliation | d Department of Physics, The Ohio State University, Columbus, OH 43210, United States e Center for Materials Research, The Ohio State University, Columbus, OH 43210, United States f NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, OH 43210, United States a Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States c Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, United States b NSF Nanoscale Science and Engineering Center (NSEC), Center for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), The Ohio State University, Columbus, OH 43210, United States |
| AuthorAffiliation_xml | – name: c Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, United States – name: e Center for Materials Research, The Ohio State University, Columbus, OH 43210, United States – name: f NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, OH 43210, United States – name: a Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States – name: d Department of Physics, The Ohio State University, Columbus, OH 43210, United States – name: b NSF Nanoscale Science and Engineering Center (NSEC), Center for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), The Ohio State University, Columbus, OH 43210, United States |
| Author_xml | – sequence: 1 givenname: Xiaogang surname: Pan fullname: Pan, Xiaogang organization: Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States – sequence: 2 givenname: Jingjiao surname: Guan fullname: Guan, Jingjiao organization: NSF Nanoscale Science and Engineering Center (NSEC), Center for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), The Ohio State University, Columbus, OH 43210, United States – sequence: 3 givenname: Jung-Woo surname: Yoo fullname: Yoo, Jung-Woo organization: Department of Physics, The Ohio State University, Columbus, OH 43210, United States – sequence: 4 givenname: Arthur J. surname: Epstein fullname: Epstein, Arthur J. organization: Department of Physics, The Ohio State University, Columbus, OH 43210, United States – sequence: 5 givenname: L. James surname: Lee fullname: Lee, L. James organization: NSF Nanoscale Science and Engineering Center (NSEC), Center for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), The Ohio State University, Columbus, OH 43210, United States – sequence: 6 givenname: Robert J. surname: Lee fullname: Lee, Robert J. email: lee.1339@osu.edu organization: Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States |
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| Keywords | Gene delivery Transferrin Cationic lipid Magnetofection Magnetic nanoparticles Pharmaceutical technology Nanoparticle Lipids Genetic transfer Magnetic Microparticle Cations Gene therapy |
| Language | English |
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| SubjectTerms | Biological and medical sciences Cationic lipid Cations - chemistry Cell Survival Chemical Phenomena Chemistry, Physical DNA - administration & dosage Drug Delivery Systems Electromagnetic Fields Electrophoresis, Agar Gel Excipients Gene delivery Gene Transfer Techniques General pharmacology Humans KB Cells Lipids Magnetic nanoparticles Magnetics Magnetofection Medical sciences Nanoparticles - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids - administration & dosage Transfection Transferrin Transferrin - administration & dosage Transferrin - chemistry |
| Title | Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery |
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