Serotonergic Modulation of Intrinsic Functional Connectivity

• Published in: Current biology Vol. 24; no. 19; pp. 2314 - 2318
• Main Authors: Schaefer, Alexander, Burmann, Inga, Regenthal, Ralf, Arélin, Katrin, Barth, Claudia, Pampel, André, Villringer, Arno, Margulies, Daniel S., Sacher, Julia
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 06.10.2014
• Subjects: Adult; Brain - drug effects; Brain - physiology; cerebellum; Citalopram - pharmacology; Connectome; Cross-Over Studies; Double-Blind Method; emotions; Female; Humans; Male; Random Allocation; serotonin; Serotonin - metabolism; Serotonin Uptake Inhibitors - pharmacology; thalamus; Young Adult

Serotonin functions as an essential neuromodulator that serves a multitude of roles, most prominently balancing mood [1]. Serotonergic challenge has been observed to reduce intrinsic functional connectivity in brain regions implicated in mood regulation [2–4]. However, the full scope of serotonergic...