Biochemical Characterization of a Regulatory Cascade Controlling Transcription of the Pseudomonas aeruginosa Type III Secretion System

• Published in: The Journal of biological chemistry Vol. 282; no. 9; pp. 6136 - 6142
• Main Authors: Zheng, Zhida, Chen, Guozhou, Joshi, Shreyas, Brutinel, Evan D., Yahr, Timothy L., Chen, Lingling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.03.2007; American Society for Biochemistry and Molecular Biology
• Subjects: Bacterial Proteins; Bodily Secretions; Multiprotein Complexes - physiology; Protein Binding; Pseudomonas aeruginosa; Pseudomonas aeruginosa - genetics; Recombinant Fusion Proteins; Repressor Proteins; Trans-Activators; Transcription Factors - metabolism; Transcription Factors - physiology; Transcription, Genetic

Many Gram-negative pathogens utilize type III secretion systems (T3SS) to translocate effector proteins into eukaryotic host cells. Expression of T3SS genes is highly regulated and is often coupled to type III secretory activity. Transcription of the Pseudomonas aeruginosa T3SS genes is coupled to s...