HIPK2-mediated transcriptional control of NMDA receptor subunit expression regulates neuronal survival and cell death

• Published in: The Journal of neuroscience Vol. 38; no. 16; pp. 4006 - 4019
• Main Authors: Shang, Yulei, Zhang, Jiasheng, Huang, Eric J
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.04.2018
• Subjects: Apoptosis; Brain; c-Jun protein; Cell death; Cell interactions; Cell survival; Cyclic AMP response element-binding protein; Glutamic acid receptors (ionotropic); HIPK2 protein; Mental disorders; Mitochondria; N-Methyl-D-aspartic acid receptors; Proteins; Receptors; Toxins; Transcription factors

NMDA ( -methyl -aspartate) receptors are critical for neuronal communication. Dysfunction in NMDA receptors has been implicated in neuropsychiatric diseases. While it is well-recognized that the composition of NMDA receptors undergoes a GluN2B-to-GluN2A switch in early postnatal life, the mechanism...