A Retrospective Analysis of BCR-ABL1 Kinase Domain Mutations in the Frontline Drug Intolerant or Resistant Chronic Myeloid Leukemia Patients: An Indian Experience from a High-End Referral Laboratory

• Published in: South Asian journal of cancer Vol. 13; no. 2; pp. 132 - 141
• Main Authors: Majumdar, Atreye, Katara, Rahul, Mishra, Avshesh, Gupta, Aastha, Sharma, Deepak K., Srivastava, Aman K., Sharma, Shivani, Jaiswal, Ankita, Dixit, Mallika, Kumar, Vipin, Kumar, Sachin, Kumar, Varun, Sharma, Rahul, Mohanty, Sambit K.
• Format: Journal Article
• Language: English
• Published: India Thieme Medical and Scientific Publishers Pvt. Ltd 01.04.2024
• Subjects: BCR-ABL1; chronic myeloid leukemia; kinase domain mutations; Original; Sanger sequencing; therapy resistance; tyrosine kinase inhibitors; tyrosine kinase inhibitors; chronic myeloid leukemia; Sanger sequencing; kinase domain mutations; BCR-ABL1; therapy resistance

Objective This article identifies and evaluates the frequency of mutations in the BCR-ABL1 kinase domain (KD) of chronic myeloid leukemia (CML) patients who showed suboptimal response to their current tyrosine kinase inhibitor (TKI) regime and assesses their clinical value in further treatment decis...