Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans

• Published in: The Journal of clinical investigation Vol. 88; no. 3; pp. 833 - 840
• Main Authors: DE FEO, P, GAN GAISANO, M, HAYMOND, M. W
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.09.1991
• Subjects: Adult; albumin; Albumins - biosynthesis; Amino Acids - blood; Biological and medical sciences; Carbon Dioxide - metabolism; Catecholamines - blood; Diabetes Mellitus, Type 1 - metabolism; Endocrinopathies; Female; fibrinogen; Fibrinogen - biosynthesis; Humans; Hydrogen-Ion Concentration; Insulin - deficiency; Leucine - metabolism; Male; Medical sciences; Human; Pathophysiology; Experimental study; Metabolism; Diabetes mellitus

Insulin deficiency decreases tissue protein synthesis, albumin mRNA concentration, and albumin synthesis in rats. In contrast, insulin deficiency does not change, or, paradoxically, increases estimates of whole body protein synthesis in humans. To determine if such estimates of whole body protein sy...