Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS

• Published in: The Journal of immunology (1950) Vol. 194; no. 4; pp. 1545 - 1554
• Main Authors: Ma, Feng, Li, Bing, Liu, Su-yang, Iyer, Shankar S, Yu, Yongxin, Wu, Aiping, Cheng, Genhong
• Format: Journal Article
• Language: English
• Published: United States 15.02.2015
• Subjects: Animals; Cell Line; Chromatin Immunoprecipitation; Enzyme-Linked Immunosorbent Assay; Feedback, Physiological; Herpes simplex virus 1; Humans; Immunity, Innate - immunology; Immunoblotting; Interferon Type I - biosynthesis; Interferon Type I - immunology; Macrophages - immunology; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nucleotidyltransferases - immunology; Nucleotidyltransferases - metabolism; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction

Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an important role in sensing cytosolic DNA and triggering STING dependent signaling to induce IFN-I. However,...