Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study
Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain. Sixteen patients with MDD and 16 h...
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| Published in | Psychiatry investigation Vol. 12; no. 2; pp. 227 - 234 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Neuropsychiatric Association
01.04.2015
대한신경정신의학회 |
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| Online Access | Get full text |
| ISSN | 1738-3684 1976-3026 |
| DOI | 10.4306/pi.2015.12.2.227 |
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| Abstract | Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.
The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.
There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD. |
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| AbstractList | Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.
The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.
There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD. Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.OBJECTIVEEvidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.METHODSSixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.RESULTSThe CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD.CONCLUSIONThere are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD. ObjectiveaaEvidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain. MethodsaaSixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps. ResultsaaThe CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls. ConclusionaaThere are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD. KCI Citation Count: 9 |
| Author | Shen, Ting Li, Cao Wang, Biao Peng, Dai-hui Yang, Wei-min Zhang, Chen Xu, Yi-feng Qiu, Mei-hui Liu, Jun Wu, Zhiguo |
| AuthorAffiliation | 2 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China 1 Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China 3 Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China 4 Huashan Hospital, Fudan University, Shanghai, China |
| AuthorAffiliation_xml | – name: 4 Huashan Hospital, Fudan University, Shanghai, China – name: 3 Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China – name: 1 Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – name: 2 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China |
| Author_xml | – sequence: 1 givenname: Ting surname: Shen fullname: Shen, Ting organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 2 givenname: Cao surname: Li fullname: Li, Cao organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 3 givenname: Biao surname: Wang fullname: Wang, Biao organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 4 givenname: Wei-min surname: Yang fullname: Yang, Wei-min organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 5 givenname: Chen surname: Zhang fullname: Zhang, Chen organization: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China – sequence: 6 givenname: Zhiguo surname: Wu fullname: Wu, Zhiguo organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 7 givenname: Mei-hui surname: Qiu fullname: Qiu, Mei-hui organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China – sequence: 8 givenname: Jun surname: Liu fullname: Liu, Jun organization: Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China – sequence: 9 givenname: Yi-feng surname: Xu fullname: Xu, Yi-feng organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China., Huashan Hospital, Fudan University, Shanghai, China – sequence: 10 givenname: Dai-hui surname: Peng fullname: Peng, Dai-hui organization: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China |
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| Keywords | Functional magnetic resonance imaging Depression Resting state Cognition connectivity network First episode |
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| Title | Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study |
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