The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

• Published in: Molecular cell Vol. 79; no. 4; pp. 660 - 676.e8
• Main Authors: Horisawa, Kenichi, Udono, Miyako, Ueno, Kazuko, Ohkawa, Yasuyuki, Nagasaki, Masao, Sekiya, Sayaka, Suzuki, Atsushi
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 20.08.2020
• Subjects: cell proliferation; direct reprogramming; gene expression; hepatocyte; liver; pioneer factor; RNA polymerase II; transactivation domain; transcription factor; transcriptional activation; transcription factor; hepatocyte; cell proliferation; liver; direct reprogramming; transactivation domain; pioneer factor; RNA polymerase II; transcriptional activation; gene expression

Specific combinations of two transcription factors (Hnf4α plus Foxa1, Foxa2, or Foxa3) can induce direct conversion of mouse fibroblasts into hepatocyte-like cells. However, the molecular mechanisms underlying hepatic reprogramming are largely unknown. Here, we show that the Foxa protein family memb...