A Central Extended Amygdala Circuit That Modulates Anxiety

• Published in: The Journal of neuroscience Vol. 38; no. 24; pp. 5567 - 5583
• Main Authors: Ahrens, Sandra, Wu, Melody V, Furlan, Alessandro, Hwang, Ga-Ram, Paik, Raehum, Li, Haohong, Penzo, Mario A, Tollkuhn, Jessica, Li, Bo
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 13.06.2018
• Subjects: Amygdala; Anxiety; Circuits; Dynorphin; ErbB-2 protein; Field tests; Inhibition; Mice; Mouse devices; Neurons; Open-field behavior; Pharmacology; Reduction; Rodents; Signaling; Somatostatin; Stria terminalis; anxiety; stress; BNST; dynorphin; ErbB4; central amygdala

Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been implicated in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit and cellular mechanisms have remained elusive. Here we show that mice with gene deficiency in somatostatin-expressing...