Context-Dependent Regulatory Mechanism of the Splicing Factor hnRNP L

• Published in: Molecular cell Vol. 37; no. 2; pp. 223 - 234
• Main Authors: Motta-Mena, Laura B., Heyd, Florian, Lynch, Kristen W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.01.2010
• Subjects: CD45 antigen; Exons; Heterogeneous-Nuclear Ribonucleoprotein L - physiology; Humans; Leukocyte Common Antigens - chemistry; Leukocyte Common Antigens - genetics; Leukocyte Common Antigens - metabolism; Models, Genetic; PROTEINS; RNA; RNA Splice Sites; RNA Splicing; RNA; PROTEINS

Splicing regulatory proteins often have distinct activities when bound to exons versus introns. However, less clear is whether variables aside from location can influence activity. HnRNP L binds to a motif present in both CD45 variable exons 4 and 5 to affect their coordinate repression. Here, we sh...