Recombination and Replication in DNA Repair of Heavily Irradiated Deinococcus radiodurans

• Published in: Cell Vol. 136; no. 6; pp. 1044 - 1055
• Main Authors: Slade, Dea, Lindner, Ariel B., Paul, Gregory, Radman, Miroslav
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.03.2009
• Subjects: Bacterial Proteins - metabolism; Deinococcus - enzymology; Deinococcus - genetics; Deinococcus - metabolism; Deinococcus - radiation effects; Deinococcus radiodurans; DNA; DNA Damage; DNA Polymerase III; DNA Repair - drug effects; DNA Replication - drug effects; DNA-Binding Proteins - metabolism; DNA-Directed DNA Polymerase; Gamma Rays; Genome, Bacterial; Hydroxyurea - pharmacology; MICROBIO; Rec A Recombinases - metabolism; Recombination, Genetic; DNA; MICROBIO

Deinococcus radiodurans' extreme resistance to ionizing radiation, desiccation, and DNA-damaging chemicals involves a robust DNA repair that reassembles its shattered genome. The repair process requires diploidy and commences with an extensive exonucleolytic erosion of DNA fragments. Liberated...