Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 7; pp. 1676 - 1690
• Main Authors: Fidanzi-Dugas, Chloë, Liagre, Bertrand, Chemin, Guillaume, Perraud, Aurélie, Carrion, Claire, Couquet, Claude-Yves, Granet, Robert, Sol, Vincent, Léger, David Yannick
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2017; Elsevier
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Cancer; cell communication; Cell Line, Tumor; CHO Cells; Cricetulus; Cyclooxygenase; death; DNA fragmentation; enzyme-linked immunosorbent assay; gels; Humans; in vivo studies; Life Sciences; Male; neoplasm cells; Photochemotherapy; Photodynamic therapy; photosensitizing agents; Photosensitizing Agents - therapeutic use; phototoxicity; polyamines; Polyamines - pharmacology; Polyamines - therapeutic use; Porphyrin; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; protoporphyrin; Protoporphyrins - pharmacology; Protoporphyrins - therapeutic use; Reactive Oxygen Species - metabolism; therapeutics; tissues; transcription factor NF-kappa B; Xenograft Model Antitumor Assays; PpIX-dSd; PDT; PGE2; PS; Photodynamic therapy; COX-2; PpIX; PTS; PA; PpIX-PA; NAC; Cyclooxygenase; Porphyrin; ALA; PpIX-dSm; ROS; Prostate cancer; Apoptosis

Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulat...