Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons

• Published in: Environmental toxicology and pharmacology Vol. 40; no. 3; pp. 758 - 763
• Main Authors: Yang, Mihi, Youn, Je-In, Kim, Seung Joon, Park, Jong Y.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Adult; Chlorella; Chlorella vulgaris; Chlorella vulgaris - chemistry; Clinical trial; Cross-Over Studies; Dietary Supplements; DNA - drug effects; DNA Methylation - drug effects; Double-Blind Method; Emergency; Epigenesis, Genetic - drug effects; Epigenetic; Female; Global methylation; Humans; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - administration & dosage; Polycyclic Aromatic Hydrocarbons - toxicity; Pyrenes - urine; Random Allocation; Tablets; Young Adult; Clinical trial; Chlorella; Epigenetic; Global methylation; Polycyclic aromatic hydrocarbons

•Chlorella reduced urinary1-OHP and global hypermethylation.•Chlorella induced association between urinary 1-OHP and global methylation.•Chlorella may affect ADME of PAHs and epigenetic alteration. DNA methylation in promoter region can be a new chemopreventive marker against polycyclic aromatic hyd...