Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients

• Published in: Heart and vessels Vol. 31; no. 11; pp. 1826 - 1833
• Main Authors: Masaki, Mitsuru, Mano, Toshiaki, Eguchi, Akiyo, Fujiwara, Shohei, Sugahara, Masataka, Hirotani, Shinichi, Tsujino, Takeshi, Komamura, Kazuo, Koshiba, Masahiro, Masuyama, Tohru
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.11.2016; Springer Nature B.V
• Subjects: Amlodipine - therapeutic use; Antagonist drugs; Atrial Function, Left - drug effects; Atrial Remodeling - drug effects; Biomarkers - blood; Biomedical Engineering and Bioengineering; Blood Pressure - drug effects; Calcium Channel Blockers - therapeutic use; Calcium Channels, L-Type - drug effects; Calcium Channels, N-Type - drug effects; Cardiac Surgery; Cardiology; China; Clinical outcomes; Diastole; Dihydropyridines - therapeutic use; Down-Regulation; Drug therapy; Echocardiography, Doppler; Female; Humans; Hypertension; Hypertension - blood; Hypertension - diagnostic imaging; Hypertension - drug therapy; Hypertension - physiopathology; Hyperuricemia - blood; Hyperuricemia - diagnosis; Hyperuricemia - drug therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Time Factors; Treatment Outcome; Uric Acid - blood; Vascular Surgery; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left - drug effects; Hypertension; Diastolic dysfunction; L- and N-type calcium channel blocking drugs; Uric acid

Left ventricular (LV) diastolic dysfunction is associated with hypertension and hyperuricemia. However, it is not clear whether the L- and N-type calcium channel blocker will improve LV diastolic dysfunction through the reduction of uric acid. The aim of this study was to investigate the effects of...