Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology

• Published in: Journal of psychopharmacology (Oxford) Vol. 30; no. 4; p. 330
• Main Authors: Smith, Christopher T, Weafer, Jessica, Cowan, Ronald L, Kessler, Robert M, Palmer, Abraham A, de Wit, Harriet, Zald, David H
• Format: Journal Article
• Language: English
• Published: United States 01.04.2016
• Subjects: Adult; Behavior, Addictive - blood; Behavior, Addictive - chemically induced; Behavior, Addictive - metabolism; Central Nervous System Stimulants - blood; Central Nervous System Stimulants - pharmacokinetics; Central Nervous System Stimulants - pharmacology; Dextroamphetamine - blood; Dextroamphetamine - pharmacokinetics; Dextroamphetamine - pharmacology; Dose-Response Relationship, Drug; Female; Heart Rate - drug effects; Humans; Individuality; Male; Substance-Related Disorders - blood; Substance-Related Disorders - etiology; Substance-Related Disorders - metabolism; Surveys and Questionnaires; Young Adult; pharmacokinetics; d-amphetamine; subjective effects; addiction; individual differences

Rate of delivery of psychostimulants has been associated with their positive euphoric effects and potential addiction liability. However, information on individual differences in onset of d-amphetamine's effects remains scarce. We examined individual differences in the time to peak subjective a...