MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity

• Published in: Molecular and cellular endocrinology Vol. 393; no. 1-2; pp. 65 - 74
• Main Authors: Chen, Ling, Dai, Yong-Mei, Ji, Chen-Bo, Yang, Lei, Shi, Chun-Mei, Xu, Guang-Feng, Pang, Ling-Xia, Huang, Fang-Yan, Zhang, Chun-Mei, Guo, Xi-Rong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 05.08.2014
• Subjects: Adipocyte proliferation and differentiation; adipocytes; Adipocytes - pathology; adipogenesis; Adipogenesis - genetics; animal disease models; Animals; Blotting, Western; brown adipose tissue; Cell Cycle - genetics; Cell Differentiation; Cell Proliferation; Diet-induced obese mouse; epididymis; Gene Expression Regulation; Human visceral obesity; Human visceral preadipocytes; Humans; KLF7; luciferase; metabolic syndrome; Mice; Mice, Obese; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; MiR-146b; obesity; Obesity - genetics; Real-Time Polymerase Chain Reaction; risk factors; stem cells; transcription factors; Human visceral preadipocytes; MiR-146b; KLF7; Diet-induced obese mouse; Adipocyte proliferation and differentiation; Human visceral obesity

•MiR-146b, highly expressed in mature adipocytes while lowly in human mesenchymal stem cells and visceral preadipocytes.•Gain-and loss-of-function studies indicated that miR-146b could affect visceral adipogenesis.•MiR-146b in human visceral adipocytes could inhibit both of KLF7 mRNA and protein lev...