Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 26; pp. E3421 - E3430
• Main Authors: Rai, Prashant, Marcus Parrish, Ian Jun Jie Tay, Na Li, Shelley Ackerman, Fang He, Jimmy Kwang, Vincent T. Chow, Bevin P. Engelward
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 30.06.2015; National Acad Sciences
• Series: PNAS Plus
• Subjects: Animals; antibiotics; Apoptosis; Biological Sciences; Cells; cytotoxicity; death; Deoxyribonucleic acid; DNA; DNA Damage; DNA Repair; Epithelial Cells - pathology; Female; genes; Genotoxicity; Gram-positive bacteria; host-pathogen relationships; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Ku80; Lungs; Mice; Mice, Inbred BALB C; pathogenicity; PNAS Plus; pneumonia; Pulmonary Alveoli - cytology; Pulmonary Alveoli - metabolism; Streptococcus; Streptococcus pneumoniae; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - pathogenicity; vaccines; Virulence; γH2AX; Ku80; DNA damage; γH2AX; hydrogen peroxide; Streptococcus pneumoniae

Significance Streptococcus pneumoniae is the most common cause of pneumonia, a leading cause of death globally. Limitations in antibiotic efficacy and vaccines call attention to the need to develop our understanding of host–pathogen interactions to improve mitigation strategies. Here, we show that...