CB1 Receptor Signaling Modulates Amygdalar Plasticity during Context-Cocaine Memory Reconsolidation to Promote Subsequent Cocaine Seeking

• Published in: The Journal of neuroscience Vol. 41; no. 4; pp. 613 - 629
• Main Authors: Higginbotham, Jessica A, Wang, Rong, Richardson, Ben D, Shiina, Hiroko, Tan, Shi Min, Presker, Mark A, Rossi, David J, Fuchs, Rita A
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 27.01.2021
• Subjects: Adaptation; Amygdala; Amygdala - drug effects; Animals; Associative memory; Cannabinoid CB1 receptors; Cocaine; Cocaine - pharmacology; Cocaine-Related Disorders - physiopathology; Cocaine-Related Disorders - psychology; Context; Cytoskeleton; Destabilization; Drug abuse; Drug-Seeking Behavior - drug effects; EGR-1 protein; Endocannabinoid system; Endocannabinoids - physiology; Excitatory postsynaptic potentials; Excitatory Postsynaptic Potentials - drug effects; Extinction, Psychological - drug effects; Gene expression; Gene Expression Regulation - drug effects; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Inhibition (psychology); Male; Membrane trafficking; Memory Consolidation - drug effects; N-Methyl-D-aspartic acid receptors; Neuronal Plasticity - drug effects; Phosphorylation; Plasticity; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - drug effects; Receptors; Retrieval; Self Administration; Signaling; Synaptic plasticity; Therapeutic targets; Zinc finger proteins; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; endocannabinoid; amygdala; CB1; cocaine; reinstatement; memory reconsolidation

Contextual drug-associated memories precipitate craving and relapse in cocaine users. Such associative memories can be weakened through interference with memory reconsolidation, a process by which memories are maintained following memory retrieval-induced destabilization. We hypothesized that cocain...