Recruitment of Condensin to Replication Origin Regions by ParB/SpoOJ Promotes Chromosome Segregation in B. subtilis

• Published in: Cell Vol. 137; no. 4; pp. 685 - 696
• Main Authors: Gruber, Stephan, Errington, Jeff
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2009
• Subjects: Adenosine Triphosphatases - metabolism; Bacillus subtilis; Bacillus subtilis - chemistry; Bacillus subtilis - genetics; Bacillus subtilis - metabolism; Bacterial Proteins - metabolism; Cell Cycle Proteins - metabolism; CELLBIO; CELLCYCLE; Chromosomes, Bacterial - metabolism; DNA-Binding Proteins - metabolism; Gene Deletion; MICROBIO; Multiprotein Complexes - metabolism; Operon; Replication Origin; CELLBIO; CELLCYCLE; MICROBIO

Proper segregation of DNA replication products is essential in all cells. In Bacillus subtilis, two protein complexes have been implicated in this process: the ParAB homologs, Soj and Spo0J, and the bacterial Smc/ScpAB complex, also called condensin. Here we demonstrate that Smc is highly enriched i...