Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro

• Published in: Viruses Vol. 14; no. 4; p. 740
• Main Authors: Seki, Yohei, Kitamura, Tomoya, Tezuka, Kenta, Murata, Megumi, Akari, Hirofumi, Hamaguchi, Isao, Okuma, Kazu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.03.2022; MDPI
• Subjects: Animals; Antiviral agents; Antiviral drugs; Chemotherapy; Deltaretrovirus Infections - genetics; envelope protein; Enzymes; Genomes; Glucose transporter; Heparan sulfate; HTLV-1; HTLV-1 surrogate model; Human T-lymphotropic virus 1 - genetics; Immunotherapy; Infections; Leukemia; Leukemia, T-Cell; Lymphocytes T; Medical prognosis; Plasmids; Proteins; recombinant VSV; Reporter gene; RNA polymerase; Simian T-lymphotropic virus 1 - genetics; STLV-1; Stomatitis; Vectors (Biology); Vesicular Stomatitis; Vesiculovirus; Viral envelope proteins; viral receptor; Viruses; England; United Kingdom > UK; United States > US; Japan; HTLV-1; STLV-1; recombinant VSV; envelope protein; viral receptor; HTLV-1 surrogate model

Human T-cell leukemia virus type 1 (HTLV-1) causes serious and intractable diseases in some carriers after infection. The elimination of infected cells is considered important to prevent this onset, but there are currently no means by which to accomplish this. We previously developed “virotherapy”,...