The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 34; no. 6; pp. 1146 - 1154
• Main Authors: Impellizzeri, Daniela, Bruschetta, Giuseppe, Di Paola, Rosanna, Ahmad, Akbar, Campolo, Michela, Cuzzocrea, Salvatore, Esposito, Emanuela, Navarra, Michele
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2015
• Subjects: adhesion; Administration, Oral; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; antioxidant activity; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - genetics; bcl-2-Associated X Protein - metabolism; Benzenesulfonates; Beverages - analysis; body weight changes; Citrus - chemistry; Citrus bergamia; Colitis; Colitis - chemically induced; Colitis - drug therapy; colon; Colon - drug effects; Colon - metabolism; Cytokines; diarrhea; Disease Models, Animal; flavonoids; Gastroenterology and Hepatology; health promotion; humans; immunohistochemistry; Inflammation; inflammatory bowel disease; Inflammatory Bowel Diseases - drug therapy; intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; interleukins; juices; Male; Mice; mitogen-activated protein kinase; mucosa; myeloperoxidase; Neutrophil Infiltration - drug effects; neutrophils; NF-kappa B - genetics; NF-kappa B - metabolism; Oxidative stress; P-Selectin - genetics; P-Selectin - metabolism; Peroxidase - metabolism; Plant Extracts - pharmacology; Poly Adenosine Diphosphate Ribose - metabolism; staining; sulfonic acids; transcription factor NF-kappa B; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tyrosine - analogs & derivatives; Tyrosine - metabolism; Up-Regulation; Citrus bergamia; PAR; Oxidative stress; CD; Cytokines; Inflammation; IBDs; IL-1β; MPO; NF-κB; TNF-α; ROS; Colitis; DNBS; BJe; Apoptosis; inflammatory bowel diseases; bergamot juice; poly ADP-ribose; reactive oxygen species; interleukin; dinitrobenzene sulfonic acid; Crohn's disease; myeloperoxidase; nuclear factor; tumor necrosis factor

The beneficial properties of the flavonoid fraction of bergamot juice (BJe) have been raising interest and have been the subject of recent studies, considering the potentiality of its health promoting substances. Flavonoids have demonstrated radical-scavenging and anti-inflammatory activities. The a...