The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease - Impellizzeri, Daniela; Bruschetta, Giuseppe; Di Paola, Rosanna; Ahmad, Akbar; Campolo, Michela; Cuzzocrea, Salvatore; Esposito, Emanuela; Navarra, Michele (Clinical nutrition (Edinburgh, Scotland), 2015)
Keywords: adhesion; Administration, Oral; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; antioxidant activity; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - genetics; bcl-2-Associated X Protein - metabolism; Benzenesulfonates; Beverages - analysis; body weight changes; Citrus - chemistry; Citrus bergamia; Colitis; Colitis - chemically induced; Colitis - drug therapy; colon; Colon - drug effects; Colon - metabolism; Cytokines; diarrhea; Disease Models, Animal; flavonoids; Gastroenterology and Hepatology; health promotion; humans; immunohistochemistry; Inflammation; inflammatory bowel disease; Inflammatory Bowel Diseases - drug therapy; intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; interleukins; juices; Male; Mice; mitogen-activated protein kinase; mucosa; myeloperoxidase; Neutrophil Infiltration - drug effects; neutrophils; NF-kappa B - genetics; NF-kappa B - metabolism; Oxidative stress; P-Selectin - genetics; P-Selectin - metabolism; Peroxidase - metabolism; Plant Extracts - pharmacology; Poly Adenosine Diphosphate Ribose - metabolism; staining; sulfonic acids; transcription factor NF-kappa B; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tyrosine - analogs & derivatives; Tyrosine - metabolism; Up-Regulation; Citrus bergamia; PAR; Oxidative stress; CD; Cytokines; Inflammation; IBDs; IL-1β; MPO; NF-κB; TNF-α; ROS; Colitis; DNBS; BJe; Apoptosis; inflammatory bowel diseases; bergamot juice; poly ADP-ribose; reactive oxygen species; interleukin; dinitrobenzene sulfonic acid; Crohn's disease; myeloperoxidase; nuclear factor; tumor necrosis factor