Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation

• Published in: Nature cell biology Vol. 9; no. 4; pp. 461 - 469
• Main Authors: Pasparakis, Manolis, Gareus, Ralph, Huth, Marion, Breiden, Bernadette, Nenci, Arianna, Rösch, Nora, Haase, Ingo, Bloch, Wilhelm, Sandhoff, Konrad
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2007
• Subjects: Ablation; Animals; Animals, Newborn; Biology; Cell Differentiation - genetics; Cell Differentiation - physiology; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Deregulation; Epidermis; Epidermis - cytology; Epidermis - metabolism; Epidermis - ultrastructure; Female; Forelimb - abnormalities; Forelimb - blood supply; Forelimb - metabolism; Gene Expression Profiling; Genetic aspects; Genetic transcription; Genotype & phenotype; I-kappa B Kinase - deficiency; I-kappa B Kinase - genetics; I-kappa B Kinase - metabolism; Keratin; Keratinocytes; Keratinocytes - cytology; Keratinocytes - metabolism; Kinases; Lipid Metabolism; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Mutation; Physiological aspects; Reverse Transcriptase Polymerase Chain Reaction; Skin Diseases - genetics; Skin Diseases - metabolism; Transcription, Genetic - drug effects; Tretinoin - pharmacology; Germany

The kinase IKK1 (also known as IKKα) was previously reported to regulate epidermal development and skeletal morphogenesis by acting in keratinocytes to induce their differentiation in an NF-κB independent manner. Here, we show that mice with epidermal keratinocyte-specific IKK1 ablation (hereafter r...