SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7

• Published in: The Journal of immunology (1950) Vol. 194; no. 10; pp. 4737 - 4749
• Main Authors: Guo, Hao, Zhang, Jialong, Zhang, Xuyuan, Wang, Yanbing, Yu, Haisheng, Yin, Xiangyun, Li, Jingyun, Du, Peishuang, Plumas, Joel, Chaperot, Laurence, Chen, Jianzhu, Su, Lishan, Liu, Yongjun, Zhang, Liguo
• Format: Journal Article
• Language: English
• Published: United States 15.05.2015
• Subjects: Blotting, Western; Cells, Cultured; Dendritic Cells - immunology; Dendritic Cells - metabolism; Endosomes - metabolism; Enterovirus; Flow Cytometry; Fluorescent Antibody Technique; Humans; Influenza virus; Interferon Regulatory Factor-7 - metabolism; Interferon Type I - biosynthesis; Lysosomal Membrane Proteins - immunology; Lysosomal Membrane Proteins - metabolism; Protein Transport - physiology; Real-Time Polymerase Chain Reaction; Receptors, Scavenger - immunology; Receptors, Scavenger - metabolism; Toll-Like Receptor 9 - metabolism

Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blo...