SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7
Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blo...
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| Published in | The Journal of immunology (1950) Vol. 194; no. 10; pp. 4737 - 4749 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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15.05.2015
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| Abstract | Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell line GEN2.2 dramatically reduces CpG-induced type I IFN production. Detailed studies reveal that SCARB2 localizes in late endosome/lysosome of pDCs, and knockdown of SCARB2 does not affect CpG oligodeoxynucleotide uptake but results in the retention of TLR9 in the endoplasmic reticulum and an impaired nuclear translocation of IFN regulatory factor 7. The IFN-I production by TLR7 ligand stimulation is also impaired by SCARB2 knockdown. However, SCARB2 is not essential for influenza virus or HSV-induced IFN-I production. These findings suggest that SCARB2 regulates TLR9-dependent IFN-I production of pDCs by mediating endosomal translocation of TLR9 and nuclear translocation of IFN regulatory factor 7. |
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| AbstractList | Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell line GEN2.2 dramatically reduces CpG-induced type I IFN production. Detailed studies reveal that SCARB2 localizes in late endosome/lysosome of pDCs, and knockdown of SCARB2 does not affect CpG oligodeoxynucleotide uptake but results in the retention of TLR9 in the endoplasmic reticulum and an impaired nuclear translocation of IFN regulatory factor 7. The IFN-I production by TLR7 ligand stimulation is also impaired by SCARB2 knockdown. However, SCARB2 is not essential for influenza virus or HSV-induced IFN-I production. These findings suggest that SCARB2 regulates TLR9-dependent IFN-I production of pDCs by mediating endosomal translocation of TLR9 and nuclear translocation of IFN regulatory factor 7. Abstract Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell line GEN2.2 dramatically reduces CpG-induced type I IFN production. Detailed studies reveal that SCARB2 localizes in late endosome/lysosome of pDCs, and knockdown of SCARB2 does not affect CpG oligodeoxynucleotide uptake but results in the retention of TLR9 in the endoplasmic reticulum and an impaired nuclear translocation of IFN regulatory factor 7. The IFN-I production by TLR7 ligand stimulation is also impaired by SCARB2 knockdown. However, SCARB2 is not essential for influenza virus or HSV-induced IFN-I production. These findings suggest that SCARB2 regulates TLR9-dependent IFN-I production of pDCs by mediating endosomal translocation of TLR9 and nuclear translocation of IFN regulatory factor 7. Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both beta -glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell line GEN2.2 dramatically reduces CpG-induced type I IFN production. Detailed studies reveal that SCARB2 localizes in late endosome/lysosome of pDCs, and knockdown of SCARB2 does not affect CpG oligodeoxynucleotide uptake but results in the retention of TLR9 in the endoplasmic reticulum and an impaired nuclear translocation of IFN regulatory factor 7. The IFN-I production by TLR7 ligand stimulation is also impaired by SCARB2 knockdown. However, SCARB2 is not essential for influenza virus or HSV-induced IFN-I production. These findings suggest that SCARB2 regulates TLR9-dependent IFN-I production of pDCs by mediating endosomal translocation of TLR9 and nuclear translocation of IFN regulatory factor 7. |
| Author | Chaperot, Laurence Su, Lishan Plumas, Joel Li, Jingyun Yin, Xiangyun Zhang, Xuyuan Yu, Haisheng Wang, Yanbing Guo, Hao Chen, Jianzhu Du, Peishuang Zhang, Liguo Zhang, Jialong Liu, Yongjun |
| AuthorAffiliation | Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 University of Chinese Academy of Sciences, Beijing, BJ 100080, China Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China Department of Research and Development, Etablissement Français du Sang Rhône-Alpes Grenoble, La Tronche 38701, France |
| AuthorAffiliation_xml | – name: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 – name: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 – name: Department of Research and Development, Etablissement Français du Sang Rhône-Alpes Grenoble, La Tronche 38701, France – name: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204 – name: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 – name: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 – name: University of Chinese Academy of Sciences, Beijing, BJ 100080, China – name: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China |
| Author_xml | – sequence: 1 givenname: Hao surname: Guo fullname: Guo, Hao organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; University of Chinese Academy of Sciences, Beijing, BJ 100080, China – sequence: 2 givenname: Jialong surname: Zhang fullname: Zhang, Jialong organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China – sequence: 3 givenname: Xuyuan surname: Zhang fullname: Zhang, Xuyuan organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; University of Chinese Academy of Sciences, Beijing, BJ 100080, China – sequence: 4 givenname: Yanbing surname: Wang fullname: Wang, Yanbing organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China – sequence: 5 givenname: Haisheng surname: Yu fullname: Yu, Haisheng organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; University of Chinese Academy of Sciences, Beijing, BJ 100080, China – sequence: 6 givenname: Xiangyun surname: Yin fullname: Yin, Xiangyun organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; University of Chinese Academy of Sciences, Beijing, BJ 100080, China – sequence: 7 givenname: Jingyun surname: Li fullname: Li, Jingyun organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; University of Chinese Academy of Sciences, Beijing, BJ 100080, China – sequence: 8 givenname: Peishuang surname: Du fullname: Du, Peishuang organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China – sequence: 9 givenname: Joel surname: Plumas fullname: Plumas, Joel organization: Department of Research and Development, Etablissement Français du Sang Rhône-Alpes Grenoble, La Tronche 38701, France – sequence: 10 givenname: Laurence surname: Chaperot fullname: Chaperot, Laurence organization: Department of Research and Development, Etablissement Français du Sang Rhône-Alpes Grenoble, La Tronche 38701, France – sequence: 11 givenname: Jianzhu surname: Chen fullname: Chen, Jianzhu organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 – sequence: 12 givenname: Lishan surname: Su fullname: Su, Lishan organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; and – sequence: 13 givenname: Yongjun surname: Liu fullname: Liu, Yongjun organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204 – sequence: 14 givenname: Liguo surname: Zhang fullname: Zhang, Liguo email: liguozhang@ibp.ac.cn organization: Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing, BJ 100101, China; liguozhang@ibp.ac.cn |
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| SubjectTerms | Blotting, Western Cells, Cultured Dendritic Cells - immunology Dendritic Cells - metabolism Endosomes - metabolism Enterovirus Flow Cytometry Fluorescent Antibody Technique Humans Influenza virus Interferon Regulatory Factor-7 - metabolism Interferon Type I - biosynthesis Lysosomal Membrane Proteins - immunology Lysosomal Membrane Proteins - metabolism Protein Transport - physiology Real-Time Polymerase Chain Reaction Receptors, Scavenger - immunology Receptors, Scavenger - metabolism Toll-Like Receptor 9 - metabolism |
| Title | SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7 |
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