CMV driven CD8+ T-cell activation is associated with acute rejection in lung transplantation

• Published in: Clinical immunology (Orlando, Fla.) Vol. 148; no. 1; pp. 16 - 26
• Main Authors: Roux, Antoine, Mourin, Gisèle, Fastenackels, Solène, Almeida, Jorge R., Iglesias, Maria Candela, Boyd, Anders, Gostick, Emma, Larsen, Martin, Price, David A., Sacre, Karim, Douek, Daniel C., Autran, Brigitte, Picard, Clément, Miranda, Sandra de, Sauce, Delphine, Stern, Marc, Appay, Victor
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2013
• Subjects: Acute rejection; Adult; Allergy and Immunology; Bronchoalveolar Lavage Fluid - immunology; Bronchoalveolar Lavage Fluid - virology; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - virology; Female; Flow Cytometry; Graft Rejection - immunology; Graft Rejection - virology; Humans; Immune activation; Leukocytes, Mononuclear - immunology; Longitudinal Studies; Lung transplantation; Lung Transplantation - immunology; Lymphocyte Activation - immunology; Male; Middle Aged; Prospective Studies; Statistics, Nonparametric; T-lymphocyte; IFN; AR; Cytomegalovirus; Acute rejection; APC; Lung transplantation; T-lymphocyte; Immune activation; BAL; CMV; allophycocyanin; interferon; acute rejection; cytomegalovirus; bronchoalveolar lavage

Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence o...