Cytokine patterns in greenhouse workers occupationally exposed to α-cypermethrin: An observational study

• Published in: Environmental toxicology and pharmacology Vol. 36; no. 3; pp. 796 - 800
• Main Authors: Costa, Chiara, Rapisarda, Venerando, Catania, Stefania, Di Nola, Carmelina, Ledda, Caterina, Fenga, Concettina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2013
• Subjects: 3-Phenoxybenzoic acid; Adult; Agricultural Workers' Diseases - metabolism; Benzoates - blood; biomarkers; Blood Cell Count; Cypermethrin; Cytokines; Cytokines - biosynthesis; Emergency; greenhouses; human population; Humans; immune response; Immunotoxicity; Insecticides - blood; Insecticides - toxicity; interferon-gamma; interleukin-10; interleukin-1beta; interleukin-2; interleukin-4; interleukin-5; interleukin-6; interleukin-8; leukocytes; Limit of Detection; lymphotoxin; Male; observational studies; Occupational exposure; Occupational Exposure - adverse effects; Pesticide; pyrethrins; Pyrethrins - blood; Pyrethrins - toxicity; tumor necrosis factor-alpha; LOD; IL; Cytokines; αCYP; Immunotoxicity; 3-Phenoxybenzoic acid; Occupational exposure; 3-PBA; RBC; Pesticide; HTC; Cypermethrin; GHW; US EPA; WBC; Hb; CYP; red blood cells; greenhouse workers; α-cypermethrin; hematocrit; hemoglobin concentration; white blood cells; 3-phenoxybenzoic acid; United States Environmental Protection Agency; interleukin; cypermethrin; limit of detection
• ISSN: 1382-6689; 1872-7077; 1872-7077
• DOI: 10.1016/j.etap.2013.07.004

•Pyrethroid exposure did not induce clinical signs of immunosuppression.•Pyrethroids significantly affected the levels of some cytokines in exposed subjects.•Low IL-12p70, IL-2, IL-8, γ-IFN may inhibit NK cell and cytotoxic T-cell activation.•Pyrethroid exposure may reduce host defenses against infe...