Acid–base Homeostasis and Implications to the Phenotypic Behaviors of Cancer

• Published in: Genomics, proteomics & bioinformatics Vol. 21; no. 6; pp. 1133 - 1148
• Main Authors: Zhou, Yi, Chang, Wennan, Lu, Xiaoyu, Wang, Jin, Zhang, Chi, Xu, Ying
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.12.2023; Oxford University Press
• Subjects: acidification; Acid–base homeostasis; alkalinization; bioinformatics; Cancer microenvironment; carbonate dehydratase; Fenton reaction; genome; genomics; homeostasis; humans; Iron metabolism; lactic acid; Metabolic reprogramming; metastasis; phenotype; proteomics; transcriptomics; Acid–base homeostasis; Fenton reaction; Iron metabolism; Metabolic reprogramming; Cancer microenvironment; Acid-base homeostasis

Acid–base homeostasis is a fundamental property of living cells, and its persistent disruption in human cells can lead to a wide range of diseases. In this study, we conducted a computational modeling analysis of transcriptomic data of 4750 human tissue samples of 9 cancer types in The Cancer Genome...