A novel vascularized patch enhances cell survival and modifies ventricular remodeling in a rat myocardial infarction model

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 140; no. 6; pp. 1388 - 1396.e3
• Main Authors: Zhou, Qi, Zhou, Jian-Ye, Zheng, Zhe, Zhang, Hao, Hu, Sheng-Shou
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2010; Elsevier
• Subjects: Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Blotting, Western; Cardiology. Vascular system; Cardiothoracic Surgery; Cell Survival; Coronary heart disease; Echocardiography; Heart; In Situ Nick-End Labeling; Medical sciences; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Myocardial Infarction - surgery; Myocarditis. Cardiomyopathies; Omentum - cytology; Pneumology; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cell Transplantation - methods; Tissue Scaffolds; Ventricular Remodeling; 39; VEGF; LVEF; DAPI; LVEDD; PLGA; TUNEL; Cx43; LVFS; SCF; LVESD; CABG; MI; MSC; 30; PCR; 4′-6-diamidino-2-phenylindole dihydrochloride; left ventricular end-diastolic diameter; myocardial infarction; left ventricular fractional shortening; left ventricular ejection fraction; connexin 43; polymerase chain reaction; coronary artery bypass grafting; mesenchymal stem cell; polylactic acid-co-glycolic acid; stem cell factor; left ventricular end-systolic diameter; vascular endothelial growth factor; terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling; Myocardial infarction; Prognosis; Rat; Rodentia; Cardiovascular disease; Coronary heart disease; Myocardial disease; Survival; Vascular remodeling; Vertebrata; Mammalia; Animal; Anesthesia; Models; Circulatory system; Cardiology; Cell; Patch

Although stem cells hold a great therapeutic potential for injured tissues, limited survival of transplanted stem cells has hindered the clinical application of this technology. We hypothesized that an omentum-based stem cell–supporting patch could provide adequate nutrients and microenvironment to...