In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota

• Published in: The American journal of clinical nutrition Vol. 97; no. 2; pp. 295 - 309
• Main Authors: Bode, Lisa M, Bunzel, Diana, Huch, Melanie, Cho, Gyu-Sung, Ruhland, Denise, Bunzel, Mirko, Bub, Achim, Franz, Charles MAP, Kulling, Sabine E
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutrition 01.02.2013; American Society for Clinical Nutrition, Inc
• Subjects: Actinobacteria - classification; Actinobacteria - isolation & purification; Actinobacteria - metabolism; Adult; Antioxidants; Bacteria; Bibenzyls - chemistry; Bibenzyls - metabolism; Bibenzyls - urine; Biochemistry; Biological and medical sciences; body weight; clinical nutrition; clinical trials; Dietary Supplements - analysis; feces; Feces - microbiology; Feeding. Feeding behavior; Female; Fermentation; Fundamental and applied biological sciences. Psychology; Humans; Hydroxylation; intestinal microorganisms; Kinetics; Male; Metabolism; Metabolites; Middle Aged; Molecular Structure; Molecular Typing; Phenols - administration & dosage; Phenols - chemistry; Phenols - metabolism; Phenols - urine; Polymerase chain reaction; polyphenols; quantitative polymerase chain reaction; Resveratrol; sequence analysis; Slackia; spectroscopy; Stereoisomerism; Stilbenes - analysis; Stilbenes - chemistry; Stilbenes - metabolism; Stilbenes - urine; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; World Health Organization; Young Adult; Human; In vivo; Digestive system; Gut; Resveratrol; Microflora; Metabolism; In vitro
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.3945/ajcn.112.049379

Strong interindividual differences in the microbial conversion of some dietary polyphenols have been reported. In-depth studies of trans-resveratrol metabolism by human gut microbiota, however, are lacking, and only one bacterial metabolite, namely dihydroresveratrol, has been described. The aim of...