A novel splice variant of FcγRIIa: A risk factor for anaphylaxis in patients with hypogammaglobulinemia

• Published in: Journal of allergy and clinical immunology Vol. 131; no. 5; pp. 1408 - 1416.e5
• Main Authors: van der Heijden, Joris, Geissler, Judy, van Mirre, Edwin, van Deuren, Marcel, van der Meer, Jos W.M., Salama, Abdulgabar, van den Berg, Timo K., Roos, Dirk, Kuijpers, Taco W.
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.05.2013
• Subjects: Adult; adverse effects; Agammaglobulinemia - etiology; Agammaglobulinemia - genetics; Agammaglobulinemia - immunology; alleles; Allergy and Immunology; Anaphylaxis; Anaphylaxis - complications; Anaphylaxis - genetics; Anaphylaxis - immunology; Animals; antibodies; antigen-antibody complex; calcium; common variable immunodeficiency; DNA; elastase; exons; Fcγ receptors; Female; heterozygosity; Humans; idiopathic thrombocytopenia; immunoglobulin A; immunoglobulin G; immunosuppression; intravenous immunoglobulin; intravenous injection; Kawasaki disease; Male; messenger RNA; Mice; mononuclear leukocytes; mutation; neutrophils; Neutrophils - immunology; Neutrophils - pathology; patients; Protein Isoforms - immunology; quantitative polymerase chain reaction; Receptors, IgG - genetics; Risk Factors; screening; splice variant; thrombocytopenia; IMIg; Fcγ receptors; [Ca2+]i; fMLP; ITP; IVIg; common variable immunodeficiency; elastase; CVID; FITC; Anaphylaxis; Kawasaki disease; SNP; KD; intravenous immunoglobulin; splice variant; neutrophils; FcγR; idiopathic thrombocytopenia; Fluorescein isothiocyanate; N-formyl-methionyl-leucyl-phenylalanine; Fcγ receptor; [Ca 2+] i; Intramuscular immunoglobulin; Single nucleotide polymorphism; Intracellular Ca 2+ ions

Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced ana...