A novel splice variant of FcγRIIa: A risk factor for anaphylaxis in patients with hypogammaglobulinemia
Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced ana...
Saved in:
| Published in | Journal of allergy and clinical immunology Vol. 131; no. 5; pp. 1408 - 1416.e5 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Mosby, Inc
01.05.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA.
We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions.
Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca2+ mobilization were determined in neutrophils and transfected cell lines, respectively.
A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIaexon6∗) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2Ac.742+871A>G mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2Ac.742+871A>G allele–positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIaexon6∗ was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIaexon6∗ compared with its native form, as shown by increased elastase release and intracellular calcium mobilization.
A novel splice variant, FcγRIIaexon6∗, was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIaexon6∗ can contribute to anaphylaxis in patients with CVID. |
|---|---|
| AbstractList | Background Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. Objective We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions. Methods Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca2+ mobilization were determined in neutrophils and transfected cell lines, respectively. Results A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIaexon6∗ ) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2Ac.742+871A>G mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion ( P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2Ac.742+871A>G allele–positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIaexon6∗ was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIaexon6∗ compared with its native form, as shown by increased elastase release and intracellular calcium mobilization. Conclusion A novel splice variant, FcγRIIaexon6∗ , was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIaexon6∗ can contribute to anaphylaxis in patients with CVID. Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions. Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca2+ mobilization were determined in neutrophils and transfected cell lines, respectively. A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIaexon6∗) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2Ac.742+871A>G mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2Ac.742+871A>G allele–positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIaexon6∗ was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIaexon6∗ compared with its native form, as shown by increased elastase release and intracellular calcium mobilization. A novel splice variant, FcγRIIaexon6∗, was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIaexon6∗ can contribute to anaphylaxis in patients with CVID. Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA.BACKGROUNDOur index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA.We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions.OBJECTIVEWe sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions.Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca(2+) mobilization were determined in neutrophils and transfected cell lines, respectively.METHODSNeutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca(2+) mobilization were determined in neutrophils and transfected cell lines, respectively.A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIa(exon6∗)) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2A(c.742+871A>G) mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2A(c.742+871A>G) allele-positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIa(exon6∗) was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIa(exon6∗) compared with its native form, as shown by increased elastase release and intracellular calcium mobilization.RESULTSA novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIa(exon6∗)) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2A(c.742+871A>G) mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2A(c.742+871A>G) allele-positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIa(exon6∗) was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIa(exon6∗) compared with its native form, as shown by increased elastase release and intracellular calcium mobilization.A novel splice variant, FcγRIIa(exon6∗), was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIa(exon6∗) can contribute to anaphylaxis in patients with CVID.CONCLUSIONA novel splice variant, FcγRIIa(exon6∗), was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIa(exon6∗) can contribute to anaphylaxis in patients with CVID. Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions. Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca(2+) mobilization were determined in neutrophils and transfected cell lines, respectively. A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIa(exon6∗)) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2A(c.742+871A>G) mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2A(c.742+871A>G) allele-positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIa(exon6∗) was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIa(exon6∗) compared with its native form, as shown by increased elastase release and intracellular calcium mobilization. A novel splice variant, FcγRIIa(exon6∗), was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIa(exon6∗) can contribute to anaphylaxis in patients with CVID. BACKGROUND: Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin (IVIg) associated with the presence of IgG antibodies against IgA. OBJECTIVE: We sought to determine the role of Fcγ receptor (FcγR) IIa in IVIg-induced anaphylactoid reactions. METHODS: Neutrophils and PBMCs were isolated from healthy subjects and IVIg-treated patients. FcγRIIa mRNA and DNA were analyzed by using real-time PCR and sequencing. IgG-mediated elastase release and intracellular Ca²⁺ mobilization were determined in neutrophils and transfected cell lines, respectively. RESULTS: A novel splice variant of FcγRIIa containing an expressed cryptic exon 6* (FcγRIIaᵉˣᵒⁿ⁶∗) was identified in our index patient. This exon is normally spliced out of all FcγRII isoforms, except the inhibitory FcγRIIb1. Compared with healthy control subjects, the heterozygous FCGR2Aᶜ.⁷⁴²⁺⁸⁷¹ᴬ>ᴳ mutation was more frequent in patients with CVID (n = 53, P < .013). Expression in patients with CVID was associated with anaphylaxis on IVIg infusion (P = .002). On screening of additional IVIg-treated patient cohorts, we identified 6 FCGR2Aᶜ.⁷⁴²⁺⁸⁷¹ᴬ>ᴳ allele–positive patients with Kawasaki disease (n = 208) and 1 patient with idiopathic thrombocytopenia (n = 93). None had adverse reactions to IVIg. Moreover, FcγRIIaᵉˣᵒⁿ⁶∗ was also demonstrated in asymptomatic family members. Functional studies in primary cells and transfected murine cells demonstrated enhanced cellular activation by FcγRIIaᵉˣᵒⁿ⁶∗ compared with its native form, as shown by increased elastase release and intracellular calcium mobilization. CONCLUSION: A novel splice variant, FcγRIIaᵉˣᵒⁿ⁶∗, was characterized as a low-frequency allele, coding for a gain-of-function receptor for IgG. In the presence of immune complexes, FcγRIIaᵉˣᵒⁿ⁶∗ can contribute to anaphylaxis in patients with CVID. |
| Author | Geissler, Judy van Deuren, Marcel van den Berg, Timo K. van der Heijden, Joris van der Meer, Jos W.M. Kuijpers, Taco W. Roos, Dirk van Mirre, Edwin Salama, Abdulgabar |
| Author_xml | – sequence: 1 givenname: Joris surname: van der Heijden fullname: van der Heijden, Joris organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands – sequence: 2 givenname: Judy surname: Geissler fullname: Geissler, Judy organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands – sequence: 3 givenname: Edwin surname: van Mirre fullname: van Mirre, Edwin organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands – sequence: 4 givenname: Marcel surname: van Deuren fullname: van Deuren, Marcel organization: Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands – sequence: 5 givenname: Jos W.M. surname: van der Meer fullname: van der Meer, Jos W.M. organization: Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands – sequence: 6 givenname: Abdulgabar surname: Salama fullname: Salama, Abdulgabar organization: Universitätsklinikum Charité, Institut für Transfusionsmedizin, Campus Virchow-Klinikum, Berlin, Germany – sequence: 7 givenname: Timo K. surname: van den Berg fullname: van den Berg, Timo K. organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands – sequence: 8 givenname: Dirk surname: Roos fullname: Roos, Dirk organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands – sequence: 9 givenname: Taco W. surname: Kuijpers fullname: Kuijpers, Taco W. email: t.w.kuijpers@amc.nl organization: Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23545275$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkt9qFDEYxYNU7Hb1BbyQXHozY_5OZooIS7G6UBD8cx2ymaSb7UwyJjOr-za-g2_gA_hMZtj2pmB7EULCOeeD8_vOwIkP3gDwEqMSI1y92ZU7pV1JEKYlIiVCzROwwKgRRVUTfgIW-QcXlWDNKThLaYfym9bNM3BKKGecCL4AbgV92JsOpqFz2sC9ik75EQYLL_Xf35_Xa3UOV39-RZduoFV6DBHafJRXw_bQqZ8uQefhoEZn_JjgDzdu4fYwhGvV9-q6C5upc970Tj0HT63qknlxey_Bt8v3Xy8-FlefPqwvVleFZg0fC0ZUU-uG1Jbj2jIrxKZtNw0lpOHcbmpKTMVRbaxpq4bTGnOhmOWWKYsoqyu6BK-PuUMM3yeTRtm7pE3XKW_ClCQWrGJMCMQel1ImCM9jRJa-upVOm960coiuV_Eg75rMgvoo0DGkFI2V2o25leDHqFwnMZIzNLmTMzQ5Q5OIyBnJEpB71rv0B01vjyaTu9w7E2XSGYE2rYtGj7IN7mH7u3t2nTk5rbobczBpF6boMyWJZcoG-WVepXmTMEWIYo5zwPn_Ax6b_g9l8tkf |
| CitedBy_id | crossref_primary_10_3389_fimmu_2022_836222 crossref_primary_10_3389_fimmu_2018_01809 crossref_primary_10_1016_j_jaci_2014_01_026 crossref_primary_10_3389_fimmu_2014_00254 crossref_primary_10_1007_s40521_019_0201_0 crossref_primary_10_1586_1744666X_2015_995096 crossref_primary_10_3389_fimmu_2014_00674 crossref_primary_10_1016_j_jaci_2016_03_053 crossref_primary_10_1007_s40278_013_4879_7 crossref_primary_10_3389_fimmu_2019_02237 crossref_primary_10_3389_fimmu_2019_00697 crossref_primary_10_15789_1563_0625_CRI_2029 crossref_primary_10_1155_2018_6431694 crossref_primary_10_1111_imr_12341 crossref_primary_10_2217_imt_14_54 crossref_primary_10_1016_j_jaip_2013_09_009 crossref_primary_10_3389_fimmu_2015_00011 crossref_primary_10_3389_fimmu_2017_00515 crossref_primary_10_1111_cei_13504 crossref_primary_10_3109_08830185_2015_1136306 crossref_primary_10_1016_j_clim_2014_09_006 crossref_primary_10_1111_all_15126 crossref_primary_10_3389_fimmu_2019_00464 crossref_primary_10_1016_j_jaip_2013_09_012 crossref_primary_10_1016_j_jaci_2016_02_015 crossref_primary_10_3389_fimmu_2019_01958 crossref_primary_10_1111_jth_15265 crossref_primary_10_1002_eji_201747215 crossref_primary_10_1097_ACI_0000000000000472 |
| Cites_doi | 10.1002/humu.20997 10.1182/blood-2005-12-4997 10.1111/j.1365-2249.2007.03483.x 10.1016/j.jim.2004.12.018 10.1016/S0140-6736(68)90527-8 10.1016/S0167-4889(97)00034-7 10.1016/0022-1759(93)90240-8 10.1542/peds.105.6.e78 10.1093/nar/gkg616 10.4049/jimmunol.162.7.4311 10.1084/jem.172.1.19 10.1182/blood-2011-07-367334 10.1046/j.1365-2249.1998.00571.x 10.1136/adc.67.8.1056 10.1002/(SICI)1521-4141(199811)28:11<3812::AID-IMMU3812>3.0.CO;2-N 10.1016/S0140-6736(04)16814-1 10.1046/j.1365-2249.1998.00697.x 10.1016/S0021-9258(18)53181-1 10.1046/j.1423-0410.2001.00047.x 10.1182/blood-2007-03-079913 10.1016/j.immuni.2005.11.010 10.1084/jem.170.4.1369 10.1182/blood.V85.8.2202.bloodjournal8582202 10.4049/jimmunol.166.1.531 10.4049/jimmunol.141.5.1602 10.1146/annurev.immunol.19.1.275 10.1001/archpedi.154.7.694 10.1016/j.jaci.2011.06.047 10.3109/07853899808999383 10.1097/00062752-200311000-00004 10.1038/sj.gene.6363879 10.1126/science.291.5503.484 10.1161/01.CIR.0000145143.19711.78 10.1111/j.1537-2995.2004.03316.x 10.4049/jimmunol.173.1.332 10.1023/A:1006650812886 10.4049/jimmunol.1003945 10.1136/adc.2007.126144 10.1182/blood-2008-09-179754 10.4049/jimmunol.152.2.574 10.1034/j.1399-0039.2003.00037.x |
| ContentType | Journal Article |
| Copyright | 2013 American Academy of Allergy, Asthma & Immunology American Academy of Allergy, Asthma & Immunology Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
| Copyright_xml | – notice: 2013 American Academy of Allergy, Asthma & Immunology – notice: American Academy of Allergy, Asthma & Immunology – notice: Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.jaci.2013.02.009 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6825 |
| EndPage | 1416.e5 |
| ExternalDocumentID | 23545275 10_1016_j_jaci_2013_02_009 S0091674913003151 1_s2_0_S0091674913003151 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Case Reports |
| GrantInformation_xml | – fundername: Netherlands Organization for Scientific Research grantid: HORIZON 050-71-034 – fundername: Sanquin |
| GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .XZ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 354 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8F7 8FE 8FH 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFRT ADMUD ADNMO ADVLN ADXHL AEBSH AEIPS AEKER AENEX AEUPX AFFNX AFJKZ AFPUW AFRAH AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV BPHCQ BVXVI C45 CAG CJTIS COF CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B LK8 LUGTX M27 M41 MO0 N4W N9A O-L O9- O9~ OAUVE OBH ODZKP OHH OHT OK0 OK1 OVD OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SJN SPCBC SSH SSI SSZ T5K TEORI TWZ UGJ UNMZH UV1 WH7 WOW WUQ X7M XFW YOC YQI YQJ Z5R ZGI ZXP ZY1 ~02 ~G- ~KM AACTN RIG AAYXX AGRNS CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c495t-42a98c928f518f4f77bddb9322955fb832e6508efed69538157a4f5f4af034863 |
| IEDL.DBID | .~1 |
| ISSN | 0091-6749 1097-6825 |
| IngestDate | Fri Jul 11 08:05:07 EDT 2025 Sun Aug 24 03:35:56 EDT 2025 Thu Apr 03 06:57:28 EDT 2025 Tue Jul 01 04:32:22 EDT 2025 Thu Apr 24 22:56:54 EDT 2025 Sun Apr 06 06:53:39 EDT 2025 Wed Apr 02 07:27:20 EDT 2025 Tue Aug 26 16:34:28 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | IMIg Fcγ receptors [Ca2+]i fMLP ITP IVIg common variable immunodeficiency elastase CVID FITC Anaphylaxis Kawasaki disease SNP KD intravenous immunoglobulin splice variant neutrophils FcγR idiopathic thrombocytopenia Fluorescein isothiocyanate N-formyl-methionyl-leucyl-phenylalanine Fcγ receptor [Ca 2+] i Intramuscular immunoglobulin Single nucleotide polymorphism Intracellular Ca 2+ ions |
| Language | English |
| License | Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c495t-42a98c928f518f4f77bddb9322955fb832e6508efed69538157a4f5f4af034863 |
| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 23545275 |
| PQID | 1347256957 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1746447704 proquest_miscellaneous_1347256957 pubmed_primary_23545275 crossref_citationtrail_10_1016_j_jaci_2013_02_009 crossref_primary_10_1016_j_jaci_2013_02_009 elsevier_sciencedirect_doi_10_1016_j_jaci_2013_02_009 elsevier_clinicalkeyesjournals_1_s2_0_S0091674913003151 elsevier_clinicalkey_doi_10_1016_j_jaci_2013_02_009 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-05-01 |
| PublicationDateYYYYMMDD | 2013-05-01 |
| PublicationDate_xml | – month: 05 year: 2013 text: 2013-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of allergy and clinical immunology |
| PublicationTitleAlternate | J Allergy Clin Immunol |
| PublicationYear | 2013 |
| Publisher | Mosby, Inc |
| Publisher_xml | – name: Mosby, Inc |
| References | Ibarrola, Vossebeld, Homburg, Thelen, Roos, Verhoeven (bib28) 1997; 1357 Eijkhout, van den Broek, Van Der Meer (bib18) 2003; 61 Hack, Paardekooper, Smeenk, Abbink, Eerenberg, Nuijens (bib21) 1988; 141 Burns, Glode (bib16) 2004; 364 Warmerdam, Nabben, van de Graaf, van de Winkel, Capel (bib9) 1993; 268 Sundin, Nava, Hammarstrom (bib20) 1998; 112 Su, Wu, Edberg, McKenzie, Kimberly (bib10) 2002; 3 van der Heijden, Breunis, Geissler, de Boer, van den Berg, Kuijpers (bib30) 2012; 188 Vyas, Perkins, Fudenberg (bib38) 1968; 2 Salama, Temmesfeld, Hippenstiel, Kalus, Suttorp, Kiesewetter (bib40) 2004; 44 McKenzie, Taylor, Malladi, Yuhan, Cassel, Chien (bib11) 1999; 162 Van den Herik-Oudijk, Capel, van der Bruggen, Van de Winkel (bib7) 1995; 85 van Mirre, Teeling, van der Meer, Bleeker, Hack (bib37) 2004; 173 Pricop, Redecha, Teillaud, Frey, Fridman, Sautes-Fridman (bib14) 2001; 166 Warmerdam, Van de Winkel, Gosselin, Capel (bib5) 1990; 172 Van Den Herik-Oudijk, Westerdaal, Henriquez, Capel, Van de Winkel (bib8) 1994; 152 Nimmerjahn, Ravetch (bib1) 2006; 24 Salama, Schwind, Schonhage, Genth, Cotting, Hustinx (bib29) 2001; 81 Breunis, van Mirre, Bruin, Geissler, de Boer, Peters (bib35) 2008; 111 Newburger, Takahashi, Gerber, Gewitz, Tani, Burns (bib17) 2004; 110 George, Woolf, Raskob (bib26) 1998; 30 Wolbink, Bollen, Baars, ten Berge, Swaak, Paardekooper (bib23) 1993; 163 Samuelsson, Towers, Ravetch (bib13) 2001; 291 Gilstad (bib39) 2003; 10 Wouters, Wiessenberg, Hart, Bruins, Voskuyl, Daha (bib24) 2005; 298 Bruhns, Iannascoli, England, Mancardi, Fernandez, Jorieux (bib3) 2009; 113 Brooks, Qiu, Luster, Ravetch (bib6) 1989; 170 van Sorge, van der Pol, van de Winkel (bib4) 2003; 61 Jonsson, Mancardi, Zhao, Kita, Iannascoli, Khun (bib12) 2012; 119 Teeling, De Groot, Eerenberg, Bleeker, Van Mierlo, Aarden (bib22) 1998; 114 Al-Herz, Bousfiha, Casanova, Chapel, Conley, Cunningham-Rundles (bib25) 2011; 2 Furukawa, Kishiro, Akimoto, Nagata, Shimizu, Yamashiro (bib33) 2008; 93 Ravetch, Bolland (bib2) 2001; 19 Hornung, Lindemann, Kraus, Peters, Berberich (bib43) 1998; 28 Eden, Lilleyman (bib27) 1992; 67 Rachid, Bonilla (bib41) 2012; 129 Cartegni, Wang, Zhu, Zhang, Krainer (bib36) 2003; 31 Van Mirre, Breunis, Geissler, Hack, de Boer, Roos (bib15) 2006; 108 de Albuquerque, Sato, da Silva Duarte (bib42) 2000; 20 Han, Silverman, Newman, McCrindle (bib32) 2000; 154 Breunis, van Mirre, Geissler, Laddach, Wolbink, van der Schoot (bib34) 2009; 30 Ahrens, Hoflich, Bombard, Lochs, Kiesewetter, Salama (bib19) 2008; 151 Wallace, French, Kahn, Sherry (bib31) 2000; 105 Jonsson (10.1016/j.jaci.2013.02.009_bib12) 2012; 119 Burns (10.1016/j.jaci.2013.02.009_bib16) 2004; 364 Su (10.1016/j.jaci.2013.02.009_bib10) 2002; 3 Ravetch (10.1016/j.jaci.2013.02.009_bib2) 2001; 19 Furukawa (10.1016/j.jaci.2013.02.009_bib33) 2008; 93 Warmerdam (10.1016/j.jaci.2013.02.009_bib5) 1990; 172 Al-Herz (10.1016/j.jaci.2013.02.009_bib25) 2011; 2 Rachid (10.1016/j.jaci.2013.02.009_bib41) 2012; 129 Brooks (10.1016/j.jaci.2013.02.009_bib6) 1989; 170 Bruhns (10.1016/j.jaci.2013.02.009_bib3) 2009; 113 Pricop (10.1016/j.jaci.2013.02.009_bib14) 2001; 166 Vyas (10.1016/j.jaci.2013.02.009_bib38) 1968; 2 Ibarrola (10.1016/j.jaci.2013.02.009_bib28) 1997; 1357 Gilstad (10.1016/j.jaci.2013.02.009_bib39) 2003; 10 Hornung (10.1016/j.jaci.2013.02.009_bib43) 1998; 28 Van den Herik-Oudijk (10.1016/j.jaci.2013.02.009_bib7) 1995; 85 Salama (10.1016/j.jaci.2013.02.009_bib40) 2004; 44 Nimmerjahn (10.1016/j.jaci.2013.02.009_bib1) 2006; 24 Van Den Herik-Oudijk (10.1016/j.jaci.2013.02.009_bib8) 1994; 152 Sundin (10.1016/j.jaci.2013.02.009_bib20) 1998; 112 van Sorge (10.1016/j.jaci.2013.02.009_bib4) 2003; 61 Teeling (10.1016/j.jaci.2013.02.009_bib22) 1998; 114 Wallace (10.1016/j.jaci.2013.02.009_bib31) 2000; 105 Samuelsson (10.1016/j.jaci.2013.02.009_bib13) 2001; 291 Eden (10.1016/j.jaci.2013.02.009_bib27) 1992; 67 Breunis (10.1016/j.jaci.2013.02.009_bib34) 2009; 30 George (10.1016/j.jaci.2013.02.009_bib26) 1998; 30 Van Mirre (10.1016/j.jaci.2013.02.009_bib15) 2006; 108 Newburger (10.1016/j.jaci.2013.02.009_bib17) 2004; 110 Salama (10.1016/j.jaci.2013.02.009_bib29) 2001; 81 Cartegni (10.1016/j.jaci.2013.02.009_bib36) 2003; 31 de Albuquerque (10.1016/j.jaci.2013.02.009_bib42) 2000; 20 Hack (10.1016/j.jaci.2013.02.009_bib21) 1988; 141 Warmerdam (10.1016/j.jaci.2013.02.009_bib9) 1993; 268 Wolbink (10.1016/j.jaci.2013.02.009_bib23) 1993; 163 Wouters (10.1016/j.jaci.2013.02.009_bib24) 2005; 298 Breunis (10.1016/j.jaci.2013.02.009_bib35) 2008; 111 McKenzie (10.1016/j.jaci.2013.02.009_bib11) 1999; 162 Eijkhout (10.1016/j.jaci.2013.02.009_bib18) 2003; 61 Han (10.1016/j.jaci.2013.02.009_bib32) 2000; 154 Ahrens (10.1016/j.jaci.2013.02.009_bib19) 2008; 151 van Mirre (10.1016/j.jaci.2013.02.009_bib37) 2004; 173 van der Heijden (10.1016/j.jaci.2013.02.009_bib30) 2012; 188 |
| References_xml | – volume: 28 start-page: 3812 year: 1998 end-page: 3823 ident: bib43 article-title: The CD40 TRAF family member interacting motif carries the information to rescue WEHI 231 cells from anti-IGM-induced growth arrest publication-title: Eur J Immunol – volume: 61 start-page: 189 year: 2003 end-page: 202 ident: bib4 article-title: FcgammaR polymorphisms: implications for function, disease susceptibility and immunotherapy publication-title: Tissue Antigens – volume: 67 start-page: 1056 year: 1992 end-page: 1058 ident: bib27 article-title: Guidelines for management of idiopathic thrombocytopenic purpura. The British Paediatric Haematology Group publication-title: Arch Dis Child – volume: 173 start-page: 332 year: 2004 end-page: 339 ident: bib37 article-title: Monomeric IgG in intravenous Ig preparations is a functional antagonist of FcgammaRII and FcgammaRIIIb publication-title: J Immunol – volume: 154 start-page: 694 year: 2000 end-page: 699 ident: bib32 article-title: Management and outcome of persistent or recurrent fever after initial intravenous gamma globulin therapy in acute Kawasaki disease publication-title: Arch Pediatr Adolesc Med – volume: 111 start-page: 1029 year: 2008 end-page: 1038 ident: bib35 article-title: Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura publication-title: Blood – volume: 10 start-page: 419 year: 2003 end-page: 423 ident: bib39 article-title: Anaphylactic transfusion reactions publication-title: Curr Opin Hematol – volume: 163 start-page: 67 year: 1993 end-page: 76 ident: bib23 article-title: Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway publication-title: J Immunol Methods – volume: 105 start-page: E78 year: 2000 ident: bib31 article-title: Initial intravenous gammaglobulin treatment failure in Kawasaki disease publication-title: Pediatrics – volume: 172 start-page: 19 year: 1990 end-page: 25 ident: bib5 article-title: Molecular basis for a polymorphism of human Fc gamma receptor II (CD32) publication-title: J Exp Med – volume: 30 start-page: 38 year: 1998 end-page: 44 ident: bib26 article-title: Idiopathic thrombocytopenic purpura: a guideline for diagnosis and management of children and adults. American Society of Hematology publication-title: Ann Med – volume: 162 start-page: 4311 year: 1999 end-page: 4318 ident: bib11 article-title: The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model publication-title: J Immunol – volume: 151 start-page: 455 year: 2008 end-page: 458 ident: bib19 article-title: Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment publication-title: Clin Exp Immunol – volume: 61 start-page: 213 year: 2003 end-page: 217 ident: bib18 article-title: Substitution therapy in immunodeficient patients with anti-IgA antibodies or severe adverse reactions to previous immunoglobulin therapy publication-title: Neth J Med – volume: 24 start-page: 19 year: 2006 end-page: 28 ident: bib1 article-title: Fcgamma receptors: old friends and new family members publication-title: Immunity – volume: 44 start-page: 509 year: 2004 end-page: 511 ident: bib40 article-title: A new strategy for the prevention of IgA anaphylactic transfusion reactions publication-title: Transfusion – volume: 108 start-page: 584 year: 2006 end-page: 590 ident: bib15 article-title: Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcγRII (CD32), is stable over time and unaffected by cytokines publication-title: Blood – volume: 30 start-page: E640 year: 2009 end-page: E650 ident: bib34 article-title: Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B publication-title: Hum Mutat – volume: 152 start-page: 574 year: 1994 end-page: 585 ident: bib8 article-title: Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes publication-title: J Immunol – volume: 141 start-page: 1602 year: 1988 end-page: 1609 ident: bib21 article-title: Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3. An analysis with monoclonal antibodies publication-title: J Immunol – volume: 364 start-page: 533 year: 2004 end-page: 544 ident: bib16 article-title: Kawasaki syndrome publication-title: Lancet – volume: 19 start-page: 275 year: 2001 end-page: 290 ident: bib2 article-title: IgG Fc receptors publication-title: Annu Rev Immunol – volume: 119 start-page: 2533 year: 2012 end-page: 2544 ident: bib12 article-title: Human FcgammaRIIA induces anaphylactic and allergic reactions publication-title: Blood – volume: 291 start-page: 484 year: 2001 end-page: 486 ident: bib13 article-title: Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor publication-title: Science – volume: 2 start-page: 312 year: 1968 end-page: 315 ident: bib38 article-title: Anaphylactoid transfusion reactions associated with anti-IgA publication-title: Lancet – volume: 81 start-page: 45 year: 2001 end-page: 48 ident: bib29 article-title: Rapid detection of antibodies to immunoglobulin A molecules by using the particle gel immunoassay publication-title: Vox Sang – volume: 298 start-page: 35 year: 2005 end-page: 45 ident: bib24 article-title: Complexes between C1q and C3 or C4: novel and specific markers for classical complement pathway activation publication-title: J Immunol Methods – volume: 93 start-page: 142 year: 2008 end-page: 146 ident: bib33 article-title: Effects of steroid pulse therapy on immunoglobulin-resistant Kawasaki disease publication-title: Arch Dis Child – volume: 166 start-page: 531 year: 2001 end-page: 537 ident: bib14 article-title: Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines publication-title: J Immunol – volume: 110 start-page: 2747 year: 2004 end-page: 2771 ident: bib17 article-title: Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association publication-title: Circulation – volume: 2 start-page: 54 year: 2011 ident: bib25 article-title: Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency publication-title: Front Immunol – volume: 170 start-page: 1369 year: 1989 end-page: 1385 ident: bib6 article-title: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes publication-title: J Exp Med – volume: 113 start-page: 3716 year: 2009 end-page: 3725 ident: bib3 article-title: Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses publication-title: Blood – volume: 3 start-page: S51 year: 2002 end-page: S56 ident: bib10 article-title: Genomic organization of classical human low-affinity Fcgamma receptor genes publication-title: Genes Immun – volume: 129 start-page: 628 year: 2012 end-page: 634 ident: bib41 article-title: The role of anti-IgA antibodies in causing adverse reactions to gamma globulin infusion in immunodeficient patients: a comprehensive review of the literature publication-title: J Allergy Clin Immunol – volume: 20 start-page: 77 year: 2000 end-page: 82 ident: bib42 article-title: IgG anti-IgA subclasses in common variable immunodeficiency and association with severe adverse reactions to intravenous immunoglobulin therapy publication-title: J Clin Immunol – volume: 85 start-page: 2202 year: 1995 end-page: 2211 ident: bib7 article-title: Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms publication-title: Blood – volume: 114 start-page: 264 year: 1998 end-page: 270 ident: bib22 article-title: Human intravenous immunoglobulin (IVIG) preparations degranulate human neutrophils in vitro publication-title: Clin Exp Immunol – volume: 112 start-page: 341 year: 1998 end-page: 346 ident: bib20 article-title: Induction of unresponsiveness against IgA in IgA-deficient patients on subcutaneous immunoglobulin infusion therapy publication-title: Clin Exp Immunol – volume: 31 start-page: 3568 year: 2003 end-page: 3571 ident: bib36 article-title: ESEfinder: a web resource to identify exonic splicing enhancers publication-title: Nucleic Acids Res – volume: 268 start-page: 7346 year: 1993 end-page: 7349 ident: bib9 article-title: The human low affinity immunoglobulin G Fc receptor IIC gene is a result of an unequal crossover event publication-title: J Biol Chem – volume: 1357 start-page: 348 year: 1997 end-page: 358 ident: bib28 article-title: Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa publication-title: Biochim Biophys Acta – volume: 188 start-page: 1318 year: 2012 end-page: 1324 ident: bib30 article-title: Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles publication-title: J Immunol – volume: 30 start-page: E640 year: 2009 ident: 10.1016/j.jaci.2013.02.009_bib34 article-title: Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B publication-title: Hum Mutat doi: 10.1002/humu.20997 – volume: 108 start-page: 584 year: 2006 ident: 10.1016/j.jaci.2013.02.009_bib15 article-title: Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcγRII (CD32), is stable over time and unaffected by cytokines publication-title: Blood doi: 10.1182/blood-2005-12-4997 – volume: 151 start-page: 455 year: 2008 ident: 10.1016/j.jaci.2013.02.009_bib19 article-title: Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2007.03483.x – volume: 298 start-page: 35 year: 2005 ident: 10.1016/j.jaci.2013.02.009_bib24 article-title: Complexes between C1q and C3 or C4: novel and specific markers for classical complement pathway activation publication-title: J Immunol Methods doi: 10.1016/j.jim.2004.12.018 – volume: 2 start-page: 312 year: 1968 ident: 10.1016/j.jaci.2013.02.009_bib38 article-title: Anaphylactoid transfusion reactions associated with anti-IgA publication-title: Lancet doi: 10.1016/S0140-6736(68)90527-8 – volume: 1357 start-page: 348 year: 1997 ident: 10.1016/j.jaci.2013.02.009_bib28 article-title: Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa publication-title: Biochim Biophys Acta doi: 10.1016/S0167-4889(97)00034-7 – volume: 163 start-page: 67 year: 1993 ident: 10.1016/j.jaci.2013.02.009_bib23 article-title: Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway publication-title: J Immunol Methods doi: 10.1016/0022-1759(93)90240-8 – volume: 2 start-page: 54 year: 2011 ident: 10.1016/j.jaci.2013.02.009_bib25 article-title: Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency publication-title: Front Immunol – volume: 105 start-page: E78 year: 2000 ident: 10.1016/j.jaci.2013.02.009_bib31 article-title: Initial intravenous gammaglobulin treatment failure in Kawasaki disease publication-title: Pediatrics doi: 10.1542/peds.105.6.e78 – volume: 31 start-page: 3568 year: 2003 ident: 10.1016/j.jaci.2013.02.009_bib36 article-title: ESEfinder: a web resource to identify exonic splicing enhancers publication-title: Nucleic Acids Res doi: 10.1093/nar/gkg616 – volume: 162 start-page: 4311 year: 1999 ident: 10.1016/j.jaci.2013.02.009_bib11 article-title: The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model publication-title: J Immunol doi: 10.4049/jimmunol.162.7.4311 – volume: 172 start-page: 19 year: 1990 ident: 10.1016/j.jaci.2013.02.009_bib5 article-title: Molecular basis for a polymorphism of human Fc gamma receptor II (CD32) publication-title: J Exp Med doi: 10.1084/jem.172.1.19 – volume: 119 start-page: 2533 year: 2012 ident: 10.1016/j.jaci.2013.02.009_bib12 article-title: Human FcgammaRIIA induces anaphylactic and allergic reactions publication-title: Blood doi: 10.1182/blood-2011-07-367334 – volume: 61 start-page: 213 year: 2003 ident: 10.1016/j.jaci.2013.02.009_bib18 article-title: Substitution therapy in immunodeficient patients with anti-IgA antibodies or severe adverse reactions to previous immunoglobulin therapy publication-title: Neth J Med – volume: 112 start-page: 341 year: 1998 ident: 10.1016/j.jaci.2013.02.009_bib20 article-title: Induction of unresponsiveness against IgA in IgA-deficient patients on subcutaneous immunoglobulin infusion therapy publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00571.x – volume: 67 start-page: 1056 year: 1992 ident: 10.1016/j.jaci.2013.02.009_bib27 article-title: Guidelines for management of idiopathic thrombocytopenic purpura. The British Paediatric Haematology Group publication-title: Arch Dis Child doi: 10.1136/adc.67.8.1056 – volume: 28 start-page: 3812 year: 1998 ident: 10.1016/j.jaci.2013.02.009_bib43 article-title: The CD40 TRAF family member interacting motif carries the information to rescue WEHI 231 cells from anti-IGM-induced growth arrest publication-title: Eur J Immunol doi: 10.1002/(SICI)1521-4141(199811)28:11<3812::AID-IMMU3812>3.0.CO;2-N – volume: 364 start-page: 533 year: 2004 ident: 10.1016/j.jaci.2013.02.009_bib16 article-title: Kawasaki syndrome publication-title: Lancet doi: 10.1016/S0140-6736(04)16814-1 – volume: 114 start-page: 264 year: 1998 ident: 10.1016/j.jaci.2013.02.009_bib22 article-title: Human intravenous immunoglobulin (IVIG) preparations degranulate human neutrophils in vitro publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00697.x – volume: 268 start-page: 7346 year: 1993 ident: 10.1016/j.jaci.2013.02.009_bib9 article-title: The human low affinity immunoglobulin G Fc receptor IIC gene is a result of an unequal crossover event publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)53181-1 – volume: 81 start-page: 45 year: 2001 ident: 10.1016/j.jaci.2013.02.009_bib29 article-title: Rapid detection of antibodies to immunoglobulin A molecules by using the particle gel immunoassay publication-title: Vox Sang doi: 10.1046/j.1423-0410.2001.00047.x – volume: 111 start-page: 1029 year: 2008 ident: 10.1016/j.jaci.2013.02.009_bib35 article-title: Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura publication-title: Blood doi: 10.1182/blood-2007-03-079913 – volume: 24 start-page: 19 year: 2006 ident: 10.1016/j.jaci.2013.02.009_bib1 article-title: Fcgamma receptors: old friends and new family members publication-title: Immunity doi: 10.1016/j.immuni.2005.11.010 – volume: 170 start-page: 1369 year: 1989 ident: 10.1016/j.jaci.2013.02.009_bib6 article-title: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes publication-title: J Exp Med doi: 10.1084/jem.170.4.1369 – volume: 85 start-page: 2202 year: 1995 ident: 10.1016/j.jaci.2013.02.009_bib7 article-title: Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms publication-title: Blood doi: 10.1182/blood.V85.8.2202.bloodjournal8582202 – volume: 166 start-page: 531 year: 2001 ident: 10.1016/j.jaci.2013.02.009_bib14 article-title: Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines publication-title: J Immunol doi: 10.4049/jimmunol.166.1.531 – volume: 141 start-page: 1602 year: 1988 ident: 10.1016/j.jaci.2013.02.009_bib21 article-title: Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3. An analysis with monoclonal antibodies publication-title: J Immunol doi: 10.4049/jimmunol.141.5.1602 – volume: 19 start-page: 275 year: 2001 ident: 10.1016/j.jaci.2013.02.009_bib2 article-title: IgG Fc receptors publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.19.1.275 – volume: 154 start-page: 694 year: 2000 ident: 10.1016/j.jaci.2013.02.009_bib32 article-title: Management and outcome of persistent or recurrent fever after initial intravenous gamma globulin therapy in acute Kawasaki disease publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpedi.154.7.694 – volume: 129 start-page: 628 year: 2012 ident: 10.1016/j.jaci.2013.02.009_bib41 article-title: The role of anti-IgA antibodies in causing adverse reactions to gamma globulin infusion in immunodeficient patients: a comprehensive review of the literature publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.06.047 – volume: 30 start-page: 38 year: 1998 ident: 10.1016/j.jaci.2013.02.009_bib26 article-title: Idiopathic thrombocytopenic purpura: a guideline for diagnosis and management of children and adults. American Society of Hematology publication-title: Ann Med doi: 10.3109/07853899808999383 – volume: 10 start-page: 419 year: 2003 ident: 10.1016/j.jaci.2013.02.009_bib39 article-title: Anaphylactic transfusion reactions publication-title: Curr Opin Hematol doi: 10.1097/00062752-200311000-00004 – volume: 3 start-page: S51 issue: suppl 1 year: 2002 ident: 10.1016/j.jaci.2013.02.009_bib10 article-title: Genomic organization of classical human low-affinity Fcgamma receptor genes publication-title: Genes Immun doi: 10.1038/sj.gene.6363879 – volume: 291 start-page: 484 year: 2001 ident: 10.1016/j.jaci.2013.02.009_bib13 article-title: Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor publication-title: Science doi: 10.1126/science.291.5503.484 – volume: 110 start-page: 2747 year: 2004 ident: 10.1016/j.jaci.2013.02.009_bib17 article-title: Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association publication-title: Circulation doi: 10.1161/01.CIR.0000145143.19711.78 – volume: 44 start-page: 509 year: 2004 ident: 10.1016/j.jaci.2013.02.009_bib40 article-title: A new strategy for the prevention of IgA anaphylactic transfusion reactions publication-title: Transfusion doi: 10.1111/j.1537-2995.2004.03316.x – volume: 173 start-page: 332 year: 2004 ident: 10.1016/j.jaci.2013.02.009_bib37 article-title: Monomeric IgG in intravenous Ig preparations is a functional antagonist of FcgammaRII and FcgammaRIIIb publication-title: J Immunol doi: 10.4049/jimmunol.173.1.332 – volume: 20 start-page: 77 year: 2000 ident: 10.1016/j.jaci.2013.02.009_bib42 article-title: IgG anti-IgA subclasses in common variable immunodeficiency and association with severe adverse reactions to intravenous immunoglobulin therapy publication-title: J Clin Immunol doi: 10.1023/A:1006650812886 – volume: 188 start-page: 1318 year: 2012 ident: 10.1016/j.jaci.2013.02.009_bib30 article-title: Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles publication-title: J Immunol doi: 10.4049/jimmunol.1003945 – volume: 93 start-page: 142 year: 2008 ident: 10.1016/j.jaci.2013.02.009_bib33 article-title: Effects of steroid pulse therapy on immunoglobulin-resistant Kawasaki disease publication-title: Arch Dis Child doi: 10.1136/adc.2007.126144 – volume: 113 start-page: 3716 year: 2009 ident: 10.1016/j.jaci.2013.02.009_bib3 article-title: Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses publication-title: Blood doi: 10.1182/blood-2008-09-179754 – volume: 152 start-page: 574 year: 1994 ident: 10.1016/j.jaci.2013.02.009_bib8 article-title: Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes publication-title: J Immunol doi: 10.4049/jimmunol.152.2.574 – volume: 61 start-page: 189 year: 2003 ident: 10.1016/j.jaci.2013.02.009_bib4 article-title: FcgammaR polymorphisms: implications for function, disease susceptibility and immunotherapy publication-title: Tissue Antigens doi: 10.1034/j.1399-0039.2003.00037.x |
| SSID | ssj0009389 |
| Score | 2.2761755 |
| Snippet | Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin... Background Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous... Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous immunoglobulin... BACKGROUND: Our index case was a patient with common variable immunodeficiency (CVID). She had anaphylactoid reactions on administration of intravenous... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1408 |
| SubjectTerms | Adult adverse effects Agammaglobulinemia - etiology Agammaglobulinemia - genetics Agammaglobulinemia - immunology alleles Allergy and Immunology Anaphylaxis Anaphylaxis - complications Anaphylaxis - genetics Anaphylaxis - immunology Animals antibodies antigen-antibody complex calcium common variable immunodeficiency DNA elastase exons Fcγ receptors Female heterozygosity Humans idiopathic thrombocytopenia immunoglobulin A immunoglobulin G immunosuppression intravenous immunoglobulin intravenous injection Kawasaki disease Male messenger RNA Mice mononuclear leukocytes mutation neutrophils Neutrophils - immunology Neutrophils - pathology patients Protein Isoforms - immunology quantitative polymerase chain reaction Receptors, IgG - genetics Risk Factors screening splice variant thrombocytopenia |
| Title | A novel splice variant of FcγRIIa: A risk factor for anaphylaxis in patients with hypogammaglobulinemia |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0091674913003151 https://www.clinicalkey.es/playcontent/1-s2.0-S0091674913003151 https://dx.doi.org/10.1016/j.jaci.2013.02.009 https://www.ncbi.nlm.nih.gov/pubmed/23545275 https://www.proquest.com/docview/1347256957 https://www.proquest.com/docview/1746447704 |
| Volume | 131 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqVkJcEOV3KVRG4oZC82PHNrdVxWoX1B4QlXqzHMeGVLvJqtlW5cKz8A68QR-gz8RM4ixC0EXimGgcW-P5c_zNDCGvclcYa_I8Mj6REfMyBpXyCh5Lw8HFyh5VeXScT0_Y-1N-ukUOh1wYhFUG29_b9M5ahzcHgZsHy6rCHF-FEHqFFzJZ0qVRMyZQyt98-wXzUJnsQ2CVREgdEmd6jNeZsRXCu7K-bqe6zTndFnx2Tmhyn9wL0SMd9wvcJVuufkDuHIX78YekGtO6uXRz2uK1tKOXcBIG1tHG04m9-fFxNjNv6fj6OwLKad9qh0LUSk2NZavn5qpqaVXTUGy1pfiXln75umw-m8XCYPEQBK67RWUekZPJu0-H0yg0U4gsnIFWEUuNklal0vNEeuaFKMqygOgtVZz7AhTbYbDmvCtzBVYw4cIwzz0zPs6YzLPHZLtuaveUUJn6WFlljfAxs3ACS_BDJWy6NIj5GJFk4KK2odI4NryY6wFSdqaR8xo5r-NUA-dH5PV6zLKvs7GROhs2Rw8ZpGDzNLiBjaPE30a5NqhtqxPdAqX-Q7RGhK9H_iad_5zx5SA5GtQW72JM7ZoLmCljAlRBcbGBRjCIVoWI2Yg86cVuzZs0w-bwgj_7z5Xtkbtp19gDoZvPyfbq_MK9gPBqVex3-rNPdsazD9Pjn4ZII_o |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqIgEXxD_Lr5G4odD82LHNbVWx2oVuD6iVerOcxC6pdpMV2VZw6bP0HXgDHqDP1Jm1swhBF4ljopnYGns848w3M4S8yW1hSpPnkXGJjJiTMaiUU_BYGQ4mVnpU5XQ_Hx-yj0f8aIvs9rkwCKsMZ78_01endXizE6S5s6hrzPFVCKFXGJDJEkyjvsFAfbGNwbvzXzgPlUnvA6skQvKQOeNBXiemrBHflfnCneo663Sd97myQqO75E5wH-nQz_Ae2bLNfXJzGgLkD0g9pE17Zme0w7i0pWdwFQbZ0dbRUXn54_NkYt7T4c8LRJRT32uHgttKTYN1q2fmW93RuqGh2mpH8Tct_fJ90R6b-dxg9RBErtt5bR6Sw9GHg91xFLopRCVcgpYRS42SpUql44l0zAlRVFUB7luqOHcFaLZFb806W-UK5JhwYZjjjhkXZ0zm2SOy3bSNfUKoTF2sSlUa4WJWwhUswQ9VsOrSIOhjQJJeiroMpcax48VM95iyE42S1yh5HacaJD8gb9c8C19oYyN11i-O7lNI4dDTYAc2com_cdku6G2nE90Bpf5jbw0IX3P-tj3_OeLrfudo0FsMxpjGtqcwUsYE6ILiYgONYOCuChGzAXnst91aNmmG3eEFf_qfM3tFbo0Ppnt6b7L_6Rm5na66fCCO8znZXn49tS_A11oWL1e6dAX2OyWI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+splice+variant+of+Fc%CE%B3RIIa%3A+A+risk+factor+for+anaphylaxis+in+patients+with+hypogammaglobulinemia&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=van+der+Heijden%2C+Joris&rft.au=Geissler%2C+Judy&rft.au=van+Mirre%2C+Edwin&rft.au=van+Deuren%2C+Marcel&rft.date=2013-05-01&rft.issn=0091-6749&rft.volume=131&rft.issue=5+p.1408-1416.e5&rft.spage=1408&rft.epage=1416&rft_id=info:doi/10.1016%2Fj.jaci.2013.02.009&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00916749%2FS0091674913X00053%2Fcov150h.gif |