Facile biosynthesis of Ag–ZnO nanocomposites using Launaea cornuta leaf extract and their antimicrobial activity

• Published in: Discover nano Vol. 18; no. 1; p. 142
• Main Authors: Makauki, Elizabeth, Mtavangu, Stanslaus George, Basu, Onita D., Rwiza, Mwemezi, Machunda, Revocatus
• Format: Journal Article
• Language: English
• Published: New York Springer US 17.11.2023; Springer Nature B.V; Springer
• Subjects: Antibacterial activity; antibacterial properties; Antimicrobial activity; Antimicrobial agents; Biosynthesis; Chemical properties; Chemical synthesis; Chemistry and Materials Science; E coli; Escherichia coli; Green synthesis; Launaea; Launaea cornuta; leaf extracts; Leaves; Materials Science; Metabolites; Microbial growth inhibition; Microorganisms; Molecular Medicine; Nanochemistry; Nanocomposites; Nanoparticles; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; particle size; Plant extracts; Secondary metabolites; Silver; Staphylococcus aureus; temperature; Zinc oxide; Nanoparticles; Green synthesis; Metabolites; Microbial growth inhibition
• ISSN: 2731-9229; 1931-7573; 2731-9229; 1556-276X
• DOI: 10.1186/s11671-023-03925-2

The quest to synthesize safe, non-hazardous Ag–ZnO nanoomposites (NCs) with improved physical and chemical properties has necessitated green synthesis approaches. In this research, Launaea cornuta leaf extract was proposed for the green synthesis of Ag–ZnO NCs, wherein the leaf extract was used as a reducing and capping agent. The antibacterial activity of the prepared nanoomposites was investigated against Escherichia coli and Staphylococcus aureus through the disc diffusion method. The influence of the synthesis temperature, pH, and precursor concentration on the synthesis of the Ag–ZnO NCs and antimicrobial efficacy were investigated. The nanoparticles were characterized by ATR-FTIR, XRD, UV–Vis, FESEM, and TEM. The FTIR results indicated the presence of secondary metabolites in Launaea cornuta which assisted the green synthesis of the nanoparticles. The XRD results confirmed the successful synthesis of crystalline Ag–ZnO NCs with an average particle size of 21.51 nm. The SEM and TEM images indicated the synthesized nanoparticles to be spherical in shape. The optimum synthesis conditions for Ag–ZnO NCs were at 70 °C, pH of 7, and 8% silver. Antibacterial activity results show Ag–ZnO NCs to have higher microbial inhibition on E. coli than on S. aureu s with the zones of inhibition of 21 ± 1.08 and 19.67 ± 0.47 mm, respectively. Therefore, the results suggest that Launaea cornuta leaf extract can be used for the synthesis of Ag–ZnO NCs.