Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

• Published in: Mutation research Vol. 745; no. 1-2; pp. 4 - 10
• Main Authors: Li, Yan, Chen, David H., Yan, Jian, Chen, Ying, Mittelstaedt, Roberta A., Zhang, Yongbin, Biris, Alexandru S., Heflich, Robert H., Chen, Tao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14.06.2012; Elsevier BV
• Subjects: AMES test; Animals; Antimicrobial agents; Assays; Brain; Cells; Consumer products; Consumers; Data processing; Genotoxicity; Humans; In vitro micronucleus assay; Ionizing radiation; Micronucleus Tests - methods; Mutagenesis; Mutagenicity Tests - methods; Mutant frequency; Mutants; Mutation; Nanoparticles; Nanoparticles - toxicity; Nanotechnology; Salmonella; Salmonella typhimurium - genetics; Silver; Silver - toxicity; Silver nanoparticles; Toxicity; Ames test; In vitro micronucleus assay; Silver nanoparticles; Genotoxicity

► Genotoxicity of AgNPs was assessed using the Ames test and micronucleus assay. ► The AgNPs are negative in the Ames test and positive in the micronucleus assay. ► The micronucleus assay is more appropriate than the Ames test for the evaluation. Silver nanoparticles (AgNPs) have antimicrobial prope...