Age-related dynamics of predominant methanogenic archaea in the human gut microbiome

• Published in: BMC microbiology Vol. 25; no. 1; pp. 193 - 16
• Main Authors: Mohammadzadeh, Rokhsareh, Mahnert, Alexander, Shinde, Tejus, Kumpitsch, Christina, Weinberger, Viktoria, Schmidt, Helena, Moissl-Eichinger, Christine
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.04.2025; BioMed Central; BMC
• Subjects: Adult; Adults; Age; Age Factors; Age groups; Aged; Aged, 80 and over; Aging; Analysis; Archaea; Archaea - classification; Archaea - genetics; Archaea - isolation & purification; Archaea - metabolism; Archaeabacteria; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - metabolism; Butyrate-producing bacteria; Centenarians; Composition; Esters; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome; Genomes; Genotype & phenotype; Geriatrics; Gut microbiota; Gut microbiota, methanogenic archaea; Host-bacteria relationships; Humans; Intestinal microflora; Lachnospiraceae; Male; Metabolism; Metabolites; Metagenome; Metagenomics; Methane; Methane - metabolism; Methanobacteriaceae; Methanobrevibacter - genetics; Methanogenic archaea; Methanogenic bacteria; Microbiological research; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Middle Aged; Older people; Oldest old people; Phenotypes; Phylogeny; Physiological aspects; Population; Young Adult; Young adults; Austria; United States; United States > US; Aging; Gut microbiota, methanogenic archaea; Butyrate-producing bacteria; Metagenome

The reciprocal relationship between aging and alterations in the gut microbiota is a subject of ongoing research. While the role of bacteria in the gut microbiome is well-documented, specific changes in the composition of methanogens during extreme aging and the impact of high methane production in...