Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice

• Published in: Molecular pain Vol. 20; p. 17448069241226553
• Main Authors: Boada, M Danilo, Gutierrez, Silvia, Eisenach, James C
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2024; Sage Publications Ltd
• Subjects: Animals; Electrical properties; Hormones; Hypersensitivity; Male; Mechanical properties; Mechanoreceptors; Metastases; Mice; Mice, Inbred C57BL; Nerve conduction; Nociception; Nociceptors; Nociceptors - physiology; Oxytocin; Oxytocin - pharmacology; Oxytocin - therapeutic use; Pain perception; Peripheral nerves; Radiation; Receptor mechanisms; Skin - innervation; Touch - physiology; Ultraviolet radiation; Nociception; oxytocin; pain; ultraviolet B radiation; sensitization

Ultraviolet B (UVB) radiation induces cutaneous inflammation, leading to thermal and mechanical hypersensitivity. Here, we examine the mechanical properties and profile of tactile and nociceptive peripheral afferents functionally disrupted by this injury and the role of oxytocin (OXT) as a modulator...