Chemical and biological properties of the world's most expensive spice: Saffron
Saffron ( Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The constituents of interest include crocin, crocetin, picrocrocin, and safranal which have all demonstrated health promoting properties. Previous stud...
Saved in:
| Published in | Food research international Vol. 43; no. 8; pp. 1981 - 1989 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
01.10.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0963-9969 1873-7145 |
| DOI | 10.1016/j.foodres.2010.07.033 |
Cover
Loading…
| Abstract | Saffron (
Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The constituents of interest include crocin, crocetin, picrocrocin, and safranal which have all demonstrated health promoting properties. Previous studies have found that biological activity of saffron constituents alleviate or prevent such health problems as gastric disorders, cardiovascular disease, insulin resistance, depression, premenstrual syndrome, insomnia, and anxiety. Saffron also shows promise in the prevention and maintenance of cancer due to its antioxidant properties. The present review article highlights the constituents that are important in the treatment of each disorder as well as the mechanisms. Many of the studies were conducted using purified forms of the constituents or completed on animal subjects. The need for human subjects using saffron in its natural form is evident to determine the possible health benefits of dietary saffron. |
|---|---|
| AbstractList | Saffron (Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The constituents of interest include crocin, crocetin, picrocrocin, and safranal which have all demonstrated health promoting properties. Previous studies have found that biological activity of saffron constituents alleviate or prevent such health problems as gastric disorders, cardiovascular disease, insulin resistance, depression, premenstrual syndrome, insomnia, and anxiety. Saffron also shows promise in the prevention and maintenance of cancer due to its antioxidant properties. The present review article highlights the constituents that are important in the treatment of each disorder as well as the mechanisms. Many of the studies were conducted using purified forms of the constituents or completed on animal subjects. The need for human subjects using saffron in its natural form is evident to determine the possible health benefits of dietary saffron. Saffron ( Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The constituents of interest include crocin, crocetin, picrocrocin, and safranal which have all demonstrated health promoting properties. Previous studies have found that biological activity of saffron constituents alleviate or prevent such health problems as gastric disorders, cardiovascular disease, insulin resistance, depression, premenstrual syndrome, insomnia, and anxiety. Saffron also shows promise in the prevention and maintenance of cancer due to its antioxidant properties. The present review article highlights the constituents that are important in the treatment of each disorder as well as the mechanisms. Many of the studies were conducted using purified forms of the constituents or completed on animal subjects. The need for human subjects using saffron in its natural form is evident to determine the possible health benefits of dietary saffron. |
| Author | Wang, Sunan Melnyk, John P. Marcone, Massimo F. |
| Author_xml | – sequence: 1 givenname: John P. surname: Melnyk fullname: Melnyk, John P. – sequence: 2 givenname: Sunan surname: Wang fullname: Wang, Sunan – sequence: 3 givenname: Massimo F. surname: Marcone fullname: Marcone, Massimo F. email: mmarcone@uoguelph.ca |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23328430$$DView record in Pascal Francis |
| BookMark | eNqFkU1vFDEMhiNUJLaFn4DIBcFllmTyNYFDhVYtIFXqofQcZTJOm9VsMiRpgX9Pyi4XLuuLZet5bcvvKTqJKQJCrylZU0Llh-3apzRlKOuetB5Ra8LYM7Sig2KdolycoBXRknVaS_0CnZayJYRIofQKXW_uYRecnbGNEx5DmtPd33LJaYFcAxScPK73gH-mPE_vCt6lUjH8WiCW8Ai4LMHBR3xjvc8pvkTPvZ0LvDrkM3R7efF987W7uv7ybfP5qnNci9pRTf3kJzYOXirLOLO9pN5x2SsYVC-FdNQTwsU4DmKiPbNCC9JzbYmwSo7sDL3fz213_niAUs0uFAfzbCOkh2KobsEF5fI4SsgwMMaUbujbA2pLe4LPNrpQzJLDzubfpmesHzgjjfu051xOpWTwxoVqa0ixZhvmNtI8OWO25uCMeXLGEGWaM00t_lP_W3BM92av8zYZe5fbZbc3DWCE6oZJ3ojzPQHt9Y8BsikuQHQwhQyumimFIzv-AKo7tUE |
| CitedBy_id | crossref_primary_10_1016_j_scienta_2019_108605 crossref_primary_10_1007_s11694_024_03012_9 crossref_primary_10_3390_foods11203245 crossref_primary_10_1016_j_ijgfs_2018_03_001 crossref_primary_10_3390_antiox11050932 crossref_primary_10_1002_mrc_4807 crossref_primary_10_3390_ijms21207529 crossref_primary_10_1007_s12011_018_1400_4 crossref_primary_10_1007_s12161_019_01604_6 crossref_primary_10_1016_j_jsps_2017_10_004 crossref_primary_10_1515_opag_2017_0005 crossref_primary_10_4103_1673_5374_284978 crossref_primary_10_1002_fsn3_2463 crossref_primary_10_3390_plants10030523 crossref_primary_10_3390_plants13111467 crossref_primary_10_1002_bmc_4743 crossref_primary_10_1016_j_ctim_2020_102500 crossref_primary_10_3390_foods13132033 crossref_primary_10_3390_nu13082736 crossref_primary_10_3390_ph16010058 crossref_primary_10_1007_s11250_024_04206_5 crossref_primary_10_1016_j_indcrop_2018_03_024 crossref_primary_10_3390_cancers14225682 crossref_primary_10_3390_md22010022 crossref_primary_10_1039_D3TB00925D crossref_primary_10_1021_acs_jafc_3c04494 crossref_primary_10_1016_j_foodchem_2018_08_089 crossref_primary_10_1007_s00216_016_9400_8 crossref_primary_10_1016_j_heliyon_2021_e06117 crossref_primary_10_3390_molecules28010033 crossref_primary_10_1002_elan_201600325 crossref_primary_10_1016_j_phrs_2018_11_038 crossref_primary_10_1016_j_lwt_2018_07_015 crossref_primary_10_1016_j_indcrop_2019_111803 crossref_primary_10_5812_semj_60190 crossref_primary_10_1186_1472_6882_12_69 crossref_primary_10_1007_s13738_024_03163_y crossref_primary_10_1016_j_sajb_2021_07_045 crossref_primary_10_5005_jp_journals_10024_2644 crossref_primary_10_1159_000515003 crossref_primary_10_1016_j_foodhyd_2016_11_033 crossref_primary_10_1515_jcim_2013_0011 crossref_primary_10_1186_s12870_024_05944_2 crossref_primary_10_1139_cjpp_2015_0214 crossref_primary_10_1016_j_foodchem_2014_10_107 crossref_primary_10_2174_1573394716666200302123336 crossref_primary_10_1016_j_foodcont_2020_107776 crossref_primary_10_1186_s12934_023_02287_9 crossref_primary_10_1007_s13197_018_3046_9 crossref_primary_10_1016_j_foodres_2024_115585 crossref_primary_10_1016_j_indcrop_2016_07_040 crossref_primary_10_3390_ddc3030026 crossref_primary_10_1016_j_sajb_2021_03_038 crossref_primary_10_1016_j_tifs_2019_05_005 crossref_primary_10_1134_S106636222004013X crossref_primary_10_1021_acssynbio_0c00039 crossref_primary_10_1021_acs_jafc_0c04076 crossref_primary_10_1108_BFJ_12_2018_0838 crossref_primary_10_1016_j_ultsonch_2022_105971 crossref_primary_10_1007_s00216_015_8882_0 crossref_primary_10_2174_1389201023666220104142531 crossref_primary_10_1016_j_scienta_2024_113684 crossref_primary_10_1021_acs_jafc_6b04398 crossref_primary_10_1016_j_foodhyd_2015_05_033 crossref_primary_10_1155_2024_8300428 crossref_primary_10_17660_ActaHortic_2020_1287_59 crossref_primary_10_3390_foods3030403 crossref_primary_10_5812_ircmj_61289 crossref_primary_10_1016_j_jff_2016_07_003 crossref_primary_10_1016_j_foodchem_2016_04_132 crossref_primary_10_1080_07373937_2011_645261 crossref_primary_10_1111_1471_0307_12569 crossref_primary_10_3920_QAS2013_0376 crossref_primary_10_1016_j_indcrop_2022_115707 crossref_primary_10_1039_C5RA25983E crossref_primary_10_1016_j_matpr_2022_08_246 crossref_primary_10_3390_app10041519 crossref_primary_10_3390_agriculture12010118 crossref_primary_10_1016_j_foodcont_2013_07_019 crossref_primary_10_1111_jocd_13284 crossref_primary_10_3390_foods12122322 crossref_primary_10_3390_molecules28176251 crossref_primary_10_4103_abr_abr_6_21 crossref_primary_10_3389_fnut_2024_1349006 crossref_primary_10_3390_foods11040579 crossref_primary_10_1016_j_aoas_2019_10_002 crossref_primary_10_33549_physiolres_933203 crossref_primary_10_1016_j_ifset_2018_07_003 crossref_primary_10_1186_s40816_016_0030_7 crossref_primary_10_1007_s10847_015_0555_2 crossref_primary_10_1007_s13197_013_1238_x crossref_primary_10_1016_j_jnim_2015_12_332 crossref_primary_10_3923_ajbs_2015_72_82 crossref_primary_10_1016_j_ijbiomac_2015_12_029 crossref_primary_10_1007_s11947_022_02949_3 crossref_primary_10_1016_j_foodchem_2017_02_015 crossref_primary_10_1016_j_foodchem_2017_02_136 crossref_primary_10_1155_2022_8214821 crossref_primary_10_1039_C9TB01462D crossref_primary_10_1016_j_mad_2022_111686 crossref_primary_10_1016_j_jfoodeng_2019_109766 crossref_primary_10_1002_hup_2434 crossref_primary_10_1080_01904167_2022_2063138 crossref_primary_10_1016_j_ijgfs_2023_100821 crossref_primary_10_1177_0960327116689715 crossref_primary_10_1111_1750_3841_16304 crossref_primary_10_3390_foods11152335 crossref_primary_10_1016_j_foodchem_2016_11_149 crossref_primary_10_15171_ijb_1034 crossref_primary_10_3389_fpls_2022_945291 crossref_primary_10_1007_s13399_022_03563_1 crossref_primary_10_1007_s13580_021_00349_8 crossref_primary_10_1016_j_foodchem_2014_02_068 crossref_primary_10_61186_shefa_12_2_74 crossref_primary_10_1016_j_jfca_2016_11_004 crossref_primary_10_1016_j_fbp_2021_11_002 crossref_primary_10_1002_ptr_6420 crossref_primary_10_1002_ptr_8169 crossref_primary_10_1016_j_tifs_2016_10_010 crossref_primary_10_1016_j_lwt_2019_108428 crossref_primary_10_1016_j_tifs_2021_03_032 crossref_primary_10_5812_ijcm_106845 crossref_primary_10_1016_j_ijbiomac_2024_133985 crossref_primary_10_3390_pharmaceutics14061290 crossref_primary_10_17776_csj_1419826 crossref_primary_10_1002_hup_2412 crossref_primary_10_3389_fphar_2020_00541 crossref_primary_10_1016_j_exer_2012_11_011 crossref_primary_10_1155_2022_4035033 crossref_primary_10_1016_j_jep_2024_117898 crossref_primary_10_1016_j_foodchem_2022_133450 crossref_primary_10_1007_s00394_015_1081_0 crossref_primary_10_1021_acs_jafc_8b04274 crossref_primary_10_3390_nu13030904 crossref_primary_10_1155_2021_5453047 crossref_primary_10_1007_s11694_019_00067_x crossref_primary_10_1016_j_tifs_2021_02_061 crossref_primary_10_1016_j_foodchem_2016_11_086 crossref_primary_10_3168_jds_2023_23612 crossref_primary_10_3390_molecules26237081 crossref_primary_10_1080_13543776_2017_1355909 crossref_primary_10_3390_cosmetics6040063 crossref_primary_10_1016_j_jct_2021_106555 crossref_primary_10_1016_j_sjbs_2020_01_018 crossref_primary_10_1155_2014_135048 crossref_primary_10_1016_j_foodchem_2016_01_003 crossref_primary_10_1016_j_foodchem_2016_05_149 crossref_primary_10_1371_journal_pone_0315178 crossref_primary_10_1111_nep_12849 crossref_primary_10_1016_j_prmcm_2022_100136 crossref_primary_10_1016_j_foodchem_2016_09_169 crossref_primary_10_1016_j_clnesp_2019_07_012 crossref_primary_10_1080_10408398_2020_1857682 crossref_primary_10_1080_14786419_2017_1295241 crossref_primary_10_1007_s13167_024_00358_4 crossref_primary_10_1016_j_dsx_2021_102311 crossref_primary_10_4103_1735_3327_324029 crossref_primary_10_1007_s10343_022_00677_4 crossref_primary_10_1016_j_fitote_2024_106278 crossref_primary_10_1016_j_jpba_2012_03_002 crossref_primary_10_1002_ptr_6633 crossref_primary_10_1111_jam_15680 crossref_primary_10_3389_fnut_2022_924192 crossref_primary_10_1016_j_foodres_2011_02_043 crossref_primary_10_1007_s00217_021_03953_1 crossref_primary_10_17795_jjnpp_20131 crossref_primary_10_1016_j_fct_2019_05_013 crossref_primary_10_3153_FH21031 crossref_primary_10_3389_fgene_2021_742095 crossref_primary_10_1108_PRT_02_2019_0009 crossref_primary_10_1007_s11418_015_0938_0 crossref_primary_10_1007_s11274_014_1694_0 crossref_primary_10_1002_jsfa_14093 crossref_primary_10_1016_j_fochx_2023_100992 crossref_primary_10_1038_s41598_020_66675_6 crossref_primary_10_1002_ptr_6748 crossref_primary_10_1021_jf104223k crossref_primary_10_1016_j_chemolab_2016_09_002 crossref_primary_10_1016_j_fbio_2023_103501 crossref_primary_10_1016_j_carbpol_2017_12_008 crossref_primary_10_3390_molecules23081851 crossref_primary_10_1016_j_foodchem_2022_132931 crossref_primary_10_1080_10942912_2014_968787 crossref_primary_10_1007_s10068_022_01139_3 crossref_primary_10_1016_j_tgchem_2025_100069 crossref_primary_10_1016_j_crfs_2023_100469 crossref_primary_10_1111_cote_12670 crossref_primary_10_1016_j_bse_2024_104806 crossref_primary_10_1016_j_fbio_2018_02_003 crossref_primary_10_1016_j_indcrop_2019_04_064 crossref_primary_10_1021_acsomega_0c00160 crossref_primary_10_3389_fphar_2021_830331 crossref_primary_10_1016_j_arabjc_2023_104918 crossref_primary_10_3390_molecules26061772 crossref_primary_10_1007_s12161_016_0710_4 crossref_primary_10_1007_s11011_024_01349_0 crossref_primary_10_1016_j_foodcont_2019_106736 crossref_primary_10_1021_acs_jafc_4c12576 crossref_primary_10_1016_j_jfca_2024_106973 crossref_primary_10_1016_j_jfca_2024_106730 crossref_primary_10_17660_ActaHortic_2020_1287_57 crossref_primary_10_1038_s41598_022_15907_y crossref_primary_10_1016_j_indcrop_2019_111978 crossref_primary_10_1007_s40005_019_00435_1 crossref_primary_10_3389_fpls_2020_569499 crossref_primary_10_3390_ijms16011544 crossref_primary_10_1002_ptr_4784 crossref_primary_10_3390_nu12051424 crossref_primary_10_1080_15376516_2017_1307476 crossref_primary_10_1155_2014_809037 crossref_primary_10_1002_jssc_201300601 crossref_primary_10_3390_molecules27061995 crossref_primary_10_1002_jsf2_114 crossref_primary_10_1007_s12161_014_9995_3 crossref_primary_10_1080_07315724_2017_1410867 crossref_primary_10_3390_foods10061238 crossref_primary_10_5812_gct_63608 crossref_primary_10_3390_su12104026 crossref_primary_10_1186_s12866_024_03716_4 crossref_primary_10_1016_j_jfca_2021_103915 crossref_primary_10_1016_j_talanta_2016_10_072 crossref_primary_10_1080_10826084_2018_1447583 crossref_primary_10_4236_aim_2012_23037 crossref_primary_10_1007_s12161_019_01610_8 crossref_primary_10_1021_jf400540y crossref_primary_10_3390_molecules29215144 crossref_primary_10_1016_j_ijbiomac_2016_11_038 crossref_primary_10_1016_j_lwt_2019_108280 crossref_primary_10_1007_s12010_022_04132_y crossref_primary_10_5057_ijae_IJAE_D_21_00006 crossref_primary_10_70749_ijbr_v2i02_428 crossref_primary_10_1007_s40011_014_0355_2 crossref_primary_10_1080_10408398_2020_1864279 crossref_primary_10_1016_j_foodcont_2023_110042 crossref_primary_10_1016_j_foodchem_2018_06_038 crossref_primary_10_3390_foods12091747 crossref_primary_10_1007_s00217_018_3073_9 crossref_primary_10_1016_j_btre_2016_03_006 crossref_primary_10_1007_s12161_016_0430_9 crossref_primary_10_31665_JFB_2021_14266 crossref_primary_10_1016_j_foodres_2024_115279 crossref_primary_10_1155_2022_9622546 crossref_primary_10_3389_fnut_2023_1267839 crossref_primary_10_3390_nu16142319 crossref_primary_10_34087_cbusbed_804112 crossref_primary_10_1111_jfpp_13677 crossref_primary_10_1016_j_jfca_2015_05_004 crossref_primary_10_1016_j_talo_2020_100005 crossref_primary_10_1080_14888386_2016_1246383 crossref_primary_10_1016_j_foodcont_2019_107022 |
| Cites_doi | 10.1016/j.fct.2009.05.017 10.1089/cbr.1995.10.257 10.1016/j.jep.2004.11.004 10.1021/jf901752f 10.1021/jf047989j 10.1080/10408398409527386 10.1186/1472-6882-4-12 10.1142/S0192415X05002655 10.1016/j.phymed.2008.06.005 10.1016/j.bcp.2005.07.034 10.1021/jf061932a 10.1080/01635589109514142 10.1016/S1043-4526(01)43005-1 10.1016/j.pnpbp.2006.11.010 10.1016/S0165-022X(00)00090-7 10.1002/ptr.1647 10.1002/(SICI)1098-2744(199612)17:4<235::AID-MC7>3.0.CO;2-C 10.1111/j.1745-4557.2001.tb00604.x 10.1002/jsfa.3679 10.1016/S0022-3565(25)23817-4 10.1089/dna.2007.0598 10.1016/0304-3835(91)90203-T 10.1016/j.jnutbio.2006.03.010 10.1016/j.phymed.2006.08.006 10.1097/00006842-200007000-00005 10.1016/j.fct.2008.08.018 10.17660/ActaHortic.2007.739.54 10.1016/S0367-326X(00)00138-6 10.1021/jf062638l 10.1016/j.ejphar.2006.05.038 10.1021/jf960105e 10.1007/s11418-006-0120-9 10.1021/jf950713e 10.1016/0304-3835(95)04067-6 10.1080/10408390600626511 10.1055/s-2005-871248 10.1021/jf000922l 10.1002/ptr.2597 10.1002/ptr.1749 10.1158/1535-7163.MCT-08-0762 10.1177/153537020222700104 10.1016/0021-9673(94)80628-4 10.1111/j.1471-0528.2007.01652.x 10.1016/j.ejphar.2006.09.071 10.1207/S15327914NC352_4 10.1093/jn/134.12.3479S 10.1016/j.lfs.2005.02.006 10.1007/s10354-007-0428-4 10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C |
| ContentType | Journal Article |
| Copyright | 2010 Elsevier Ltd 2015 INIST-CNRS |
| Copyright_xml | – notice: 2010 Elsevier Ltd – notice: 2015 INIST-CNRS |
| DBID | FBQ AAYXX CITATION IQODW 7QR 8FD FR3 P64 7S9 L.6 |
| DOI | 10.1016/j.foodres.2010.07.033 |
| DatabaseName | AGRIS CrossRef Pascal-Francis Chemoreception Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef Chemoreception Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | Chemoreception Abstracts AGRICOLA |
| Database_xml | – sequence: 1 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Economics Engineering |
| EISSN | 1873-7145 |
| EndPage | 1989 |
| ExternalDocumentID | 23328430 10_1016_j_foodres_2010_07_033 US201301901064 S0963996910002632 |
| GeographicLocations | World |
| GroupedDBID | --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKC AAIKJ AAKOC AALCJ AALRI AAMNW AAOAW AAQFI AAQXK AATLK AAXUO ABFNM ABFRF ABGRD ABMAC ABXDB ABYKQ ACDAQ ACGFO ACIUM ACRLP ADBBV ADEZE ADMUD ADQTV AEBSH AEFWE AEKER AENEX AEQOU AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CBWCG CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HVGLF HZ~ IHE J1W K-O KOM LW9 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAB SDF SDG SDP SES SEW SPCBC SSA SSZ T5K WUQ Y6R ~G- ~KM AAHBH AATTM AAXKI ABWVN ACRPL ADNMO AEIPS AFJKZ AKRWK ANKPU BNPGV FBQ SSH AAYWO AAYXX ACVFH ADCNI AEUPX AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKYEP APXCP CITATION EFKBS IQODW 7QR 8FD FR3 P64 7S9 L.6 |
| ID | FETCH-LOGICAL-c495t-191fdfd3b8f67a343a261fc4627e872656c1f0045bb85d123a5950249a05a76b3 |
| IEDL.DBID | .~1 |
| ISSN | 0963-9969 |
| IngestDate | Fri Sep 05 12:23:19 EDT 2025 Fri Sep 05 04:33:55 EDT 2025 Fri Aug 22 06:47:14 EDT 2025 Thu Apr 24 23:10:37 EDT 2025 Tue Jul 01 05:39:04 EDT 2025 Thu Apr 03 09:41:43 EDT 2025 Fri Feb 23 02:37:04 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Safranal Crocus sativus Health Crocetin Crocin Spice Saffron Antioxidant Picrocrocin Biological properties Iridaceae Monocotyledones Angiospermae Spermatophyta Chemical properties |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c495t-191fdfd3b8f67a343a261fc4627e872656c1f0045bb85d123a5950249a05a76b3 |
| Notes | http://dx.doi.org/10.1016/j.foodres.2010.07.033 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PQID | 1008833379 |
| PQPubID | 23462 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1999945146 proquest_miscellaneous_1008833379 pascalfrancis_primary_23328430 crossref_citationtrail_10_1016_j_foodres_2010_07_033 crossref_primary_10_1016_j_foodres_2010_07_033 fao_agris_US201301901064 elsevier_sciencedirect_doi_10_1016_j_foodres_2010_07_033 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-10-01 |
| PublicationDateYYYYMMDD | 2010-10-01 |
| PublicationDate_xml | – month: 10 year: 2010 text: 2010-10-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Kidlington |
| PublicationPlace_xml | – name: Kidlington |
| PublicationTitle | Food research international |
| PublicationYear | 2010 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Karimi, Hosseinzadeh, Khaleghpanah (bb0140) 2001; 4 Sugiura, Shoyama, Saito, Abe (bb0260) 1994; 271 Garcia-Olmo, Riese, Escribano, Ontanon, Fernandez, Atienzar (bb0075) 1999; 35 Soeda, Ochiai, Shimeno, Saito, Abe, Tanaka (bb0255) 2007; 61 Carmona, Zalacain, Salinas, Alonso (bb0050) 2007; 47 Jagadeeswaran, Thirunavukkarasu, Gunasekaran, Ramamurty, Sakthisekaran (bb0130) 2000; 71 Assimopoulou, Sinakos, Papageorgiou (bb0035) 2005; 19 Kianbakht, Mozaffari (bb0145) 2009; 8 Lozano, Delgado, Gomez, Rubio, Iborra (bb0155) 2000; 43 Morin (bb0175) 2000; 62 Papandreou, Kanakis, Polissiou, Efthimiopoulos, Cordopatis, Margarity (bb0210) 2006; 54 Xu, Li, Ma, Zhong, Liu, Ao (bb0300) 2009; 57 Dhar, Mehta, Dhar, Dhar, Banerjee, Van Veldhuizen (bb0065) 2009; 8 Rau (bb0225) 1969 Bathaie, Bolhasani, Hoshyar, Ranjbar, Sabouni, Moosavi-Movahedi (bb0040) 2007; 26 (bb0125) 2003 Pfister, Meyer, Steck, Pfander (bb0215) 1996; 44 Rios, Recio, Giner, Manez (bb0230) 1996; 10 Xi, Qian, Shen, Wen, Zhang (bb0290) 2005; 71 Tavakkol-Afshari, Brook, Mousavi (bb0275) 2008; 46 He, Qian, Wen, Tang, Xu, Zhou (bb0100) 2007; 554 Kanakis, Tarantilis, Tajmir-Riahi, Polissiou (bb0135) 2007; 55 Tarantilis, Polissiou (bb0265) 1997; 45 Hill (bb0105) 2004 Pitsikas, Boultadakis, Georgiadou, Tarantilis, Sakellaridis (bb0220) 2008; 15 Wang, Cheng, Liu, Chou, Kuo, Lin (bb0280) 1996; 17 Bisset, Wichtl (bb0045) 1994 Hosseinzadeh, Noraei (bb0115) 2009; 23 Agha-Hosseini, Kashani, Aleyaseen, Ghoreishi, Rahmanpour, Zarrinara (bb0010) 2008; 115 Nabavizadeh, Salimi, Sadroleslami, Karimian, Vahedian (bb0190) 2009; 3 Alonso, Salinas, Garijo, Sanchez-Fernadez (bb0030) 2001; 24 Hagh-Nazari, Keifi (bb0090) 2007; 739 Maggi, Carmona, del Campo, Kanakis, Anastasaki, Tarantilis (bb0165) 2009; 89 Molnar, Szabo, Pusztai, Mucsi, Berek, Ocsovszki (bb0170) 2000; 20 Mousavi, Tavakkol-Afshari, Brook, Jafari-Anarkooli (bb0185) 2009; 47 Sampathu, Shivashankar, Lewis, Wood (bb0240) 1984; 20 Zareena, Variyar, Gholap, Bongirwar (bb0305) 2001; 49 Chryssanthi, Lamari, Iatrou, Pylara, Karamanos, Cordopatis (bb0055) 2007; 27 Akhondzadeh, Fallah-Pour, Afkham, Jamshidi, Khalighi-Cigaroudi (bb0020) 2004; 4 Deo (bb0060) 2003; 20 Escribano, Alonso, Coca-Prados, Fernandez (bb0070) 1996; 100 Tarantilis, Polissiou, Manfait (bb0270) 1994; 664 Abdullaev (bb0005) 2002; 227 Zheng, Qian, Tang, Sheng (bb0310) 2005; 70 Moshiri, Akhondzadeh Basti, Noorbala, Jamshidi, Abbasi, Akhondzadeh (bb0180) 2006; 13 Gregory, Menary, Davies (bb0080) 2005; 53 He, Qian, Tang, Wen, Xu, Sheng (bb0095) 2005; 77 Lucas, Hallagan, Taylor (bb0160) 2001; 43 Sheng, Qian, Zheng, Xi (bb0250) 2006; 543 Liu (bb0150) 2004; 134 Xi, Qian, Xu, Zheng, Sun, Wen (bb0295) 2007; 18 Hosseinzadeh, Karimi, Niapoor (bb0110) 2004; 650 Nair, Kurumboor, Hasegawa (bb0195) 1995; 10 Salomi, Nair, Panikkar (bb0235) 1991; 16 Akhondzadeh, Tahmacebi-Pour, Noorbala, Amini, Fallah-Pour, Jamshidi (bb0025) 2005; 19 Nair, Pannikar, Panikkar (bb0200) 1991; 57 World Health Organization (bb0285) 2009 Schmidt, Betti, Hensel (bb0245) 2007; 157 Inoue, Shimizu, Shoji, Tsuchida, Sano, Ito (bb0120) 2005; 33 Hadizadeh, Khalili, Hosseinzadeh, Khair-Aldine (bb0085) 2003; 2 Akhondzadeh Basti, Moshiri, Noorbala, Jamshidi, Abbasi, Akhondzadeh (bb0015) 2007; 31 Noorbala, Akhondzadeh, Tahmacebi-Pour, Jamshidi (bb0205) 2005; 97 Agha-Hosseini (10.1016/j.foodres.2010.07.033_bb0010) 2008; 115 Assimopoulou (10.1016/j.foodres.2010.07.033_bb0035) 2005; 19 Noorbala (10.1016/j.foodres.2010.07.033_bb0205) 2005; 97 Salomi (10.1016/j.foodres.2010.07.033_bb0235) 1991; 16 Akhondzadeh Basti (10.1016/j.foodres.2010.07.033_bb0015) 2007; 31 Akhondzadeh (10.1016/j.foodres.2010.07.033_bb0020) 2004; 4 Hill (10.1016/j.foodres.2010.07.033_bb0105) 2004 Bathaie (10.1016/j.foodres.2010.07.033_bb0040) 2007; 26 Jagadeeswaran (10.1016/j.foodres.2010.07.033_bb0130) 2000; 71 Nair (10.1016/j.foodres.2010.07.033_bb0200) 1991; 57 Pfister (10.1016/j.foodres.2010.07.033_bb0215) 1996; 44 Rau (10.1016/j.foodres.2010.07.033_bb0225) 1969 Liu (10.1016/j.foodres.2010.07.033_bb0150) 2004; 134 Alonso (10.1016/j.foodres.2010.07.033_bb0030) 2001; 24 Molnar (10.1016/j.foodres.2010.07.033_bb0170) 2000; 20 He (10.1016/j.foodres.2010.07.033_bb0095) 2005; 77 Nabavizadeh (10.1016/j.foodres.2010.07.033_bb0190) 2009; 3 Sheng (10.1016/j.foodres.2010.07.033_bb0250) 2006; 543 Karimi (10.1016/j.foodres.2010.07.033_bb0140) 2001; 4 Lucas (10.1016/j.foodres.2010.07.033_bb0160) 2001; 43 Wang (10.1016/j.foodres.2010.07.033_bb0280) 1996; 17 Hosseinzadeh (10.1016/j.foodres.2010.07.033_bb0110) 2004; 650 Abdullaev (10.1016/j.foodres.2010.07.033_bb0005) 2002; 227 Zareena (10.1016/j.foodres.2010.07.033_bb0305) 2001; 49 Hosseinzadeh (10.1016/j.foodres.2010.07.033_bb0115) 2009; 23 Deo (10.1016/j.foodres.2010.07.033_bb0060) 2003; 20 Bisset (10.1016/j.foodres.2010.07.033_bb0045) 1994 Tavakkol-Afshari (10.1016/j.foodres.2010.07.033_bb0275) 2008; 46 Morin (10.1016/j.foodres.2010.07.033_bb0175) 2000; 62 Schmidt (10.1016/j.foodres.2010.07.033_bb0245) 2007; 157 Xi (10.1016/j.foodres.2010.07.033_bb0295) 2007; 18 Lozano (10.1016/j.foodres.2010.07.033_bb0155) 2000; 43 Nair (10.1016/j.foodres.2010.07.033_bb0195) 1995; 10 Papandreou (10.1016/j.foodres.2010.07.033_bb0210) 2006; 54 Maggi (10.1016/j.foodres.2010.07.033_bb0165) 2009; 89 Garcia-Olmo (10.1016/j.foodres.2010.07.033_bb0075) 1999; 35 Tarantilis (10.1016/j.foodres.2010.07.033_bb0265) 1997; 45 Escribano (10.1016/j.foodres.2010.07.033_bb0070) 1996; 100 Chryssanthi (10.1016/j.foodres.2010.07.033_bb0055) 2007; 27 Tarantilis (10.1016/j.foodres.2010.07.033_bb0270) 1994; 664 Dhar (10.1016/j.foodres.2010.07.033_bb0065) 2009; 8 Gregory (10.1016/j.foodres.2010.07.033_bb0080) 2005; 53 Rios (10.1016/j.foodres.2010.07.033_bb0230) 1996; 10 Zheng (10.1016/j.foodres.2010.07.033_bb0310) 2005; 70 He (10.1016/j.foodres.2010.07.033_bb0100) 2007; 554 Moshiri (10.1016/j.foodres.2010.07.033_bb0180) 2006; 13 Soeda (10.1016/j.foodres.2010.07.033_bb0255) 2007; 61 Hagh-Nazari (10.1016/j.foodres.2010.07.033_bb0090) 2007; 739 Inoue (10.1016/j.foodres.2010.07.033_bb0120) 2005; 33 Xi (10.1016/j.foodres.2010.07.033_bb0290) 2005; 71 Sugiura (10.1016/j.foodres.2010.07.033_bb0260) 1994; 271 Akhondzadeh (10.1016/j.foodres.2010.07.033_bb0025) 2005; 19 Mousavi (10.1016/j.foodres.2010.07.033_bb0185) 2009; 47 Pitsikas (10.1016/j.foodres.2010.07.033_bb0220) 2008; 15 (10.1016/j.foodres.2010.07.033_bb0125) 2003 World Health Organization (10.1016/j.foodres.2010.07.033_bb0285) 2009 Xu (10.1016/j.foodres.2010.07.033_bb0300) 2009; 57 Sampathu (10.1016/j.foodres.2010.07.033_bb0240) 1984; 20 Hadizadeh (10.1016/j.foodres.2010.07.033_bb0085) 2003; 2 Kianbakht (10.1016/j.foodres.2010.07.033_bb0145) 2009; 8 Carmona (10.1016/j.foodres.2010.07.033_bb0050) 2007; 47 Kanakis (10.1016/j.foodres.2010.07.033_bb0135) 2007; 55 |
| References_xml | – volume: 46 start-page: 3443 year: 2008 end-page: 3447 ident: bb0275 article-title: Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines publication-title: Food and Chemical Toxicology – volume: 17 start-page: 235 year: 1996 end-page: 240 ident: bb0280 article-title: Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells publication-title: Molecular Carcinogenesis – volume: 739 start-page: 411 year: 2007 end-page: 416 ident: bb0090 article-title: Saffron and various fraud manners in its production and trades publication-title: Acta Horticulturae – volume: 10 start-page: 257 year: 1995 end-page: 264 ident: bb0195 article-title: Saffron chemoprevention in biology and medicine: A review publication-title: Cancer Biotherapy – year: 2009 ident: bb0285 article-title: Cardiovascular diseases fact sheet number 317 – volume: 664 start-page: 55 year: 1994 end-page: 61 ident: bb0270 article-title: Separation of picrocrocin, publication-title: Journal of Chromatography A – volume: 47 start-page: 145 year: 2007 end-page: 159 ident: bb0050 article-title: A new approach to saffron aroma publication-title: Critical Reviews in Food Science and Nutrition – volume: 43 start-page: 367 year: 2000 end-page: 378 ident: bb0155 article-title: A non-destructive method to determine the safranal content of saffron ( publication-title: Journal of Biochemical and Biophysical Methods – volume: 47 start-page: 1909 year: 2009 end-page: 1913 ident: bb0185 article-title: Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells publication-title: Food and Chemical Toxicology – volume: 71 start-page: 395 year: 2000 end-page: 399 ident: bb0130 publication-title: Fitoterapia – volume: 53 start-page: 5969 year: 2005 end-page: 5975 ident: bb0080 article-title: Effect of drying temperature and air flow on the production and retention of secondary metabolites in saffron publication-title: Journal of Agricultural and Food Chemistry – year: 2003 ident: bb0125 article-title: Saffron ( – volume: 49 start-page: 687 year: 2001 end-page: 691 ident: bb0305 article-title: Chemical investigation of gamma-irradiated saffron ( publication-title: Journal of Agricultural and Food Chemistry – volume: 8 start-page: 315 year: 2009 end-page: 323 ident: bb0065 article-title: Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model publication-title: Molecular Cancer Therapy – volume: 8 start-page: 30 year: 2009 end-page: 38 ident: bb0145 article-title: Effects of saffron and its active constituents, crocin and safranal on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats publication-title: Journal of Medicinal Plants – volume: 71 start-page: 917 year: 2005 end-page: 922 ident: bb0290 article-title: Crocetin prevents dexamethasone-induced insulin resistance in rats publication-title: Planta Medica – volume: 70 start-page: 1192 year: 2005 end-page: 1199 ident: bb0310 article-title: Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits publication-title: Biochemical Pharmacology – volume: 77 start-page: 907 year: 2005 end-page: 921 ident: bb0095 article-title: Effect of crocin on experimental atherosclerosis in quails and its mechanisms publication-title: Life Sciences – volume: 27 start-page: 357 year: 2007 end-page: 362 ident: bb0055 article-title: Inhibition of breast cancer cell proliferation by style constituents of different publication-title: Anticancer Research – volume: 55 start-page: 970 year: 2007 end-page: 977 ident: bb0135 article-title: Crocetin, dimethylcrocetin, and safranal bind human serum albumin: Stability and antoxidative properties publication-title: Journal of Agricultural and Food Chemistry – volume: 3 start-page: 181 year: 2009 end-page: 184 ident: bb0190 article-title: Saffron ( publication-title: African Journal of Pharmacy and Pharmacology – volume: 4 start-page: 12 year: 2004 ident: bb0020 article-title: Comparison of publication-title: BMC Complementary Alternative Medicine – volume: 10 start-page: 189 year: 1996 end-page: 193 ident: bb0230 article-title: A update review of saffron and its active constituents publication-title: Phytotherapy Research – volume: 543 start-page: 116 year: 2006 end-page: 122 ident: bb0250 article-title: Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase publication-title: European Journal of Pharmacology – volume: 54 start-page: 8762 year: 2006 end-page: 8768 ident: bb0210 article-title: Inhibitory activity on amyloid-β aggregation and antioxidant properties of publication-title: Journal of Agricultural and Food Chemistry – volume: 271 start-page: 703 year: 1994 end-page: 707 ident: bb0260 article-title: Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo publication-title: The Journal of Pharmacology and Experimental Therapeutics – volume: 35 start-page: 120 year: 1999 end-page: 126 ident: bb0075 article-title: Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron ( publication-title: Nutrition and Cancer – volume: 57 start-page: 8325 year: 2009 end-page: 8330 ident: bb0300 article-title: Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells publication-title: Journal of Agricultural and Food Chemistry – volume: 13 start-page: 607 year: 2006 end-page: 611 ident: bb0180 publication-title: Phytomedicine – volume: 115 start-page: 515 year: 2008 end-page: 519 ident: bb0010 publication-title: BJOG — An International Journal of Obstetrics and Gynaecology – volume: 2 start-page: 251 year: 2003 end-page: 252 ident: bb0085 article-title: Kaempferol from saffron petals publication-title: Iranian Journal of Pharmaceutical Research – volume: 157 start-page: 315 year: 2007 end-page: 319 ident: bb0245 article-title: Saffron in phytotherapy: Pharmacology and clinical uses publication-title: Wiener Medizinische Wochenschrift – volume: 4 start-page: 11 year: 2001 end-page: 15 ident: bb0140 article-title: Study of antidepressant effect of aqueous and ethanolic extracts of publication-title: Iranian Journal of Basic Medical Science – volume: 62 start-page: 483 year: 2000 end-page: 485 ident: bb0175 article-title: The nature of insomnia and the need to refine our diagnostic criteria publication-title: Psychosomatic Medicine – volume: 20 start-page: 123 year: 1984 end-page: 157 ident: bb0240 article-title: Saffron ( publication-title: Critical Reviews in Food Science and Nutrition – volume: 61 start-page: 102 year: 2007 end-page: 111 ident: bb0255 article-title: Pharmacological activities of crocin in saffron publication-title: Journal of Natural Medicine – volume: 227 start-page: 20 year: 2002 end-page: 25 ident: bb0005 article-title: Cancer chemopreventive and tumoricidal properties of saffron ( publication-title: Experimental Biology and Medicine – volume: 33 start-page: 49 year: 2005 end-page: 60 ident: bb0120 article-title: Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood publication-title: American Journal of Chinese Medicine – year: 1969 ident: bb0225 article-title: The cooking of India (foods of the world) – volume: 20 start-page: 861 year: 2000 end-page: 867 ident: bb0170 article-title: Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates publication-title: Anticancer Research – volume: 45 start-page: 456 year: 1997 end-page: 462 ident: bb0265 article-title: Isolation and identification of the aroma components from saffron ( publication-title: Journal of Agricultural and Food Chemistry – volume: 18 start-page: 64 year: 2007 end-page: 72 ident: bb0295 article-title: Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats publication-title: Journal of Nutritional Biochemistry – volume: 31 start-page: 439 year: 2007 end-page: 442 ident: bb0015 article-title: Comparison of petal of publication-title: Progress in Neuro-Psychopharmacology & Biological Psychiatry – volume: 15 start-page: 1135 year: 2008 end-page: 1139 ident: bb0220 article-title: Effects of the active constituents of publication-title: Phytomedicine – volume: 554 start-page: 191 year: 2007 end-page: 195 ident: bb0100 article-title: Influence of crocetin on experimental atherosclerosis in hyperlipidemic-diet quails publication-title: European Journal of Pharmacology – volume: 19 start-page: 148 year: 2005 end-page: 151 ident: bb0025 publication-title: Phytotherapy Research – volume: 134 start-page: 3479S year: 2004 end-page: 3485S ident: bb0150 article-title: Potential synergy of phytochemicals in cancer prevention: Mechanism of action publication-title: Journal of Nutrition – volume: 89 start-page: 1950 year: 2009 end-page: 1954 ident: bb0165 article-title: Worldwide market screening of saffron volatile composition publication-title: Journal of the Science of Food and Agriculture – volume: 57 start-page: 109 year: 1991 end-page: 114 ident: bb0200 article-title: Antitumour activity of saffron ( publication-title: Cancer Letters – volume: 19 start-page: 997 year: 2005 end-page: 1000 ident: bb0035 article-title: Radical scavenging activity of publication-title: Phytotherapy Research – volume: 26 start-page: 533 year: 2007 end-page: 540 ident: bb0040 article-title: Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15 publication-title: DNA and Cell Biology – volume: 20 start-page: 1 year: 2003 end-page: 4 ident: bb0060 article-title: Growing saffron — The world's most expensive spice publication-title: Crop & Food Research – volume: 100 start-page: 23 year: 1996 end-page: 30 ident: bb0070 article-title: Crocin, safranal and picrocrocin from saffron ( publication-title: Cancer Letters – volume: 16 start-page: 67 year: 1991 end-page: 72 ident: bb0235 article-title: Inhibitory effects of publication-title: Nutrition and Cancer – volume: 23 start-page: 768 year: 2009 end-page: 774 ident: bb0115 article-title: Anxiolytic and hypnotic effect of publication-title: Phytotherapy Research – year: 1994 ident: bb0045 article-title: Herbal drugs and phytopharmaceuticals – year: 2004 ident: bb0105 article-title: The contemporary encyclopedia of herbs and spices: Seasonings for the global kitchen – volume: 24 start-page: 219 year: 2001 end-page: 233 ident: bb0030 article-title: Composition of crocins and picrocrocin from Spanish saffron ( publication-title: Journal of Food Quality – volume: 44 start-page: 2612 year: 1996 end-page: 2615 ident: bb0215 article-title: Isolation and structure elucidation of carotenoid-glycosol esters in gardenia fruits ( publication-title: Journal of Agricultural and Food Chemistry – volume: 650 start-page: 435 year: 2004 end-page: 445 ident: bb0110 article-title: Antidepressant effect of publication-title: Proceedings of the 1st International Symposium on Saffron Biology and Biotechnolgy – volume: 97 start-page: 281 year: 2005 end-page: 284 ident: bb0205 article-title: Hydro-alcoholic extract of publication-title: Journal of Ethnopharmacology – volume: 43 start-page: 195 year: 2001 end-page: 216 ident: bb0160 article-title: The role of natural color additives in food allergy publication-title: Advances in Food and Nutrition Research – volume: 47 start-page: 1909 issue: 8 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0185 article-title: Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2009.05.017 – volume: 10 start-page: 257 issue: 4 year: 1995 ident: 10.1016/j.foodres.2010.07.033_bb0195 article-title: Saffron chemoprevention in biology and medicine: A review publication-title: Cancer Biotherapy doi: 10.1089/cbr.1995.10.257 – volume: 97 start-page: 281 issue: 2 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0205 article-title: Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2004.11.004 – volume: 650 start-page: 435 year: 2004 ident: 10.1016/j.foodres.2010.07.033_bb0110 article-title: Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice publication-title: Proceedings of the 1st International Symposium on Saffron Biology and Biotechnolgy – year: 2003 ident: 10.1016/j.foodres.2010.07.033_bb0125 – volume: 57 start-page: 8325 issue: 18 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0300 article-title: Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf901752f – volume: 20 start-page: 861 issue: 2A year: 2000 ident: 10.1016/j.foodres.2010.07.033_bb0170 article-title: Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates publication-title: Anticancer Research – volume: 53 start-page: 5969 issue: 15 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0080 article-title: Effect of drying temperature and air flow on the production and retention of secondary metabolites in saffron publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf047989j – volume: 20 start-page: 123 issue: 2 year: 1984 ident: 10.1016/j.foodres.2010.07.033_bb0240 article-title: Saffron (Crocus sativus Linn.) — Cultivation, processing, chemistry and standardization publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408398409527386 – volume: 4 start-page: 12 year: 2004 ident: 10.1016/j.foodres.2010.07.033_bb0020 article-title: Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial publication-title: BMC Complementary Alternative Medicine doi: 10.1186/1472-6882-4-12 – volume: 33 start-page: 49 issue: 1 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0120 article-title: Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood publication-title: American Journal of Chinese Medicine doi: 10.1142/S0192415X05002655 – volume: 15 start-page: 1135 issue: 12 year: 2008 ident: 10.1016/j.foodres.2010.07.033_bb0220 article-title: Effects of the active constituents of Crocus sativus L., crocins, in animal model of anxiety publication-title: Phytomedicine doi: 10.1016/j.phymed.2008.06.005 – year: 1994 ident: 10.1016/j.foodres.2010.07.033_bb0045 – volume: 70 start-page: 1192 issue: 8 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0310 article-title: Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2005.07.034 – volume: 54 start-page: 8762 issue: 23 year: 2006 ident: 10.1016/j.foodres.2010.07.033_bb0210 article-title: Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf061932a – volume: 2 start-page: 251 year: 2003 ident: 10.1016/j.foodres.2010.07.033_bb0085 article-title: Kaempferol from saffron petals publication-title: Iranian Journal of Pharmaceutical Research – volume: 16 start-page: 67 issue: 1 year: 1991 ident: 10.1016/j.foodres.2010.07.033_bb0235 article-title: Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice publication-title: Nutrition and Cancer doi: 10.1080/01635589109514142 – volume: 43 start-page: 195 year: 2001 ident: 10.1016/j.foodres.2010.07.033_bb0160 article-title: The role of natural color additives in food allergy publication-title: Advances in Food and Nutrition Research doi: 10.1016/S1043-4526(01)43005-1 – volume: 31 start-page: 439 issue: 2 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0015 article-title: Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial publication-title: Progress in Neuro-Psychopharmacology & Biological Psychiatry doi: 10.1016/j.pnpbp.2006.11.010 – volume: 43 start-page: 367 issue: 1–3 year: 2000 ident: 10.1016/j.foodres.2010.07.033_bb0155 article-title: A non-destructive method to determine the safranal content of saffron (Crocus sativus L.) by supercritical carbon dioxide extraction combined with high-performance liquid chromatography and gas chromatography publication-title: Journal of Biochemical and Biophysical Methods doi: 10.1016/S0165-022X(00)00090-7 – volume: 19 start-page: 148 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0025 article-title: Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo controlled trial publication-title: Phytotherapy Research doi: 10.1002/ptr.1647 – year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0285 – volume: 17 start-page: 235 issue: 4 year: 1996 ident: 10.1016/j.foodres.2010.07.033_bb0280 article-title: Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells publication-title: Molecular Carcinogenesis doi: 10.1002/(SICI)1098-2744(199612)17:4<235::AID-MC7>3.0.CO;2-C – volume: 24 start-page: 219 issue: 3 year: 2001 ident: 10.1016/j.foodres.2010.07.033_bb0030 article-title: Composition of crocins and picrocrocin from Spanish saffron (Crocus sativus L.) publication-title: Journal of Food Quality doi: 10.1111/j.1745-4557.2001.tb00604.x – volume: 89 start-page: 1950 issue: 11 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0165 article-title: Worldwide market screening of saffron volatile composition publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.3679 – volume: 271 start-page: 703 issue: 2 year: 1994 ident: 10.1016/j.foodres.2010.07.033_bb0260 article-title: Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo publication-title: The Journal of Pharmacology and Experimental Therapeutics doi: 10.1016/S0022-3565(25)23817-4 – volume: 26 start-page: 533 issue: 8 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0040 article-title: Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15 publication-title: DNA and Cell Biology doi: 10.1089/dna.2007.0598 – volume: 57 start-page: 109 issue: 2 year: 1991 ident: 10.1016/j.foodres.2010.07.033_bb0200 article-title: Antitumour activity of saffron (Crocus sativus) publication-title: Cancer Letters doi: 10.1016/0304-3835(91)90203-T – volume: 18 start-page: 64 issue: 1 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0295 article-title: Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats publication-title: Journal of Nutritional Biochemistry doi: 10.1016/j.jnutbio.2006.03.010 – volume: 13 start-page: 607 issue: 9–10 year: 2006 ident: 10.1016/j.foodres.2010.07.033_bb0180 article-title: Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial publication-title: Phytomedicine doi: 10.1016/j.phymed.2006.08.006 – volume: 27 start-page: 357 issue: 1A year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0055 article-title: Inhibition of breast cancer cell proliferation by style constituents of different Crocus species publication-title: Anticancer Research – volume: 3 start-page: 181 issue: 5 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0190 article-title: Saffron (Crocus sativus) increases gastric acid and pepsin secretions in rats: Role of nitric oxide (NO) publication-title: African Journal of Pharmacy and Pharmacology – volume: 4 start-page: 11 issue: 3–11 year: 2001 ident: 10.1016/j.foodres.2010.07.033_bb0140 article-title: Study of antidepressant effect of aqueous and ethanolic extracts of Crocus sativus in mice publication-title: Iranian Journal of Basic Medical Science – volume: 62 start-page: 483 issue: 4 year: 2000 ident: 10.1016/j.foodres.2010.07.033_bb0175 article-title: The nature of insomnia and the need to refine our diagnostic criteria publication-title: Psychosomatic Medicine doi: 10.1097/00006842-200007000-00005 – year: 2004 ident: 10.1016/j.foodres.2010.07.033_bb0105 – volume: 46 start-page: 3443 issue: 11 year: 2008 ident: 10.1016/j.foodres.2010.07.033_bb0275 article-title: Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2008.08.018 – volume: 739 start-page: 411 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0090 article-title: Saffron and various fraud manners in its production and trades publication-title: Acta Horticulturae doi: 10.17660/ActaHortic.2007.739.54 – volume: 71 start-page: 395 issue: 4 year: 2000 ident: 10.1016/j.foodres.2010.07.033_bb0130 article-title: In vitro studies on the selective cytotoxic effect of crocetin and quercetin publication-title: Fitoterapia doi: 10.1016/S0367-326X(00)00138-6 – volume: 55 start-page: 970 issue: 3 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0135 article-title: Crocetin, dimethylcrocetin, and safranal bind human serum albumin: Stability and antoxidative properties publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf062638l – volume: 543 start-page: 116 issue: 1–3 year: 2006 ident: 10.1016/j.foodres.2010.07.033_bb0250 article-title: Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2006.05.038 – volume: 45 start-page: 456 issue: 2 year: 1997 ident: 10.1016/j.foodres.2010.07.033_bb0265 article-title: Isolation and identification of the aroma components from saffron (Crocus sativus) publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf960105e – volume: 61 start-page: 102 issue: 2 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0255 article-title: Pharmacological activities of crocin in saffron publication-title: Journal of Natural Medicine doi: 10.1007/s11418-006-0120-9 – volume: 44 start-page: 2612 issue: 9 year: 1996 ident: 10.1016/j.foodres.2010.07.033_bb0215 article-title: Isolation and structure elucidation of carotenoid-glycosol esters in gardenia fruits (Gardenia jasminoides Ellis) and saffron (Crocus sativus Linne) publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf950713e – volume: 100 start-page: 23 year: 1996 ident: 10.1016/j.foodres.2010.07.033_bb0070 article-title: Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro publication-title: Cancer Letters doi: 10.1016/0304-3835(95)04067-6 – volume: 47 start-page: 145 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0050 article-title: A new approach to saffron aroma publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408390600626511 – volume: 71 start-page: 917 issue: 10 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0290 article-title: Crocetin prevents dexamethasone-induced insulin resistance in rats publication-title: Planta Medica doi: 10.1055/s-2005-871248 – year: 1969 ident: 10.1016/j.foodres.2010.07.033_bb0225 – volume: 49 start-page: 687 issue: 2 year: 2001 ident: 10.1016/j.foodres.2010.07.033_bb0305 article-title: Chemical investigation of gamma-irradiated saffron (Crocus sativus L.) publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf000922l – volume: 23 start-page: 768 issue: 6 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0115 article-title: Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice publication-title: Phytotherapy Research doi: 10.1002/ptr.2597 – volume: 19 start-page: 997 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0035 article-title: Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents publication-title: Phytotherapy Research doi: 10.1002/ptr.1749 – volume: 8 start-page: 315 issue: 2 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0065 article-title: Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model publication-title: Molecular Cancer Therapy doi: 10.1158/1535-7163.MCT-08-0762 – volume: 8 start-page: 30 issue: 5 year: 2009 ident: 10.1016/j.foodres.2010.07.033_bb0145 article-title: Effects of saffron and its active constituents, crocin and safranal on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats publication-title: Journal of Medicinal Plants – volume: 227 start-page: 20 year: 2002 ident: 10.1016/j.foodres.2010.07.033_bb0005 article-title: Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.) publication-title: Experimental Biology and Medicine doi: 10.1177/153537020222700104 – volume: 664 start-page: 55 issue: 1 year: 1994 ident: 10.1016/j.foodres.2010.07.033_bb0270 article-title: Separation of picrocrocin, cis-trans-crocins and safranal of saffron using high-performance liquid chromatography with photodiode-array detection publication-title: Journal of Chromatography A doi: 10.1016/0021-9673(94)80628-4 – volume: 115 start-page: 515 issue: 4 year: 2008 ident: 10.1016/j.foodres.2010.07.033_bb0010 article-title: Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: A double-blind, randomised and placebo-controlled trial publication-title: BJOG — An International Journal of Obstetrics and Gynaecology doi: 10.1111/j.1471-0528.2007.01652.x – volume: 554 start-page: 191 issue: 2–3 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0100 article-title: Influence of crocetin on experimental atherosclerosis in hyperlipidemic-diet quails publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2006.09.071 – volume: 35 start-page: 120 issue: 2 year: 1999 ident: 10.1016/j.foodres.2010.07.033_bb0075 article-title: Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): An experimental study in the rat publication-title: Nutrition and Cancer doi: 10.1207/S15327914NC352_4 – volume: 134 start-page: 3479S issue: 12 year: 2004 ident: 10.1016/j.foodres.2010.07.033_bb0150 article-title: Potential synergy of phytochemicals in cancer prevention: Mechanism of action publication-title: Journal of Nutrition doi: 10.1093/jn/134.12.3479S – volume: 77 start-page: 907 issue: 8 year: 2005 ident: 10.1016/j.foodres.2010.07.033_bb0095 article-title: Effect of crocin on experimental atherosclerosis in quails and its mechanisms publication-title: Life Sciences doi: 10.1016/j.lfs.2005.02.006 – volume: 157 start-page: 315 issue: 13–14 year: 2007 ident: 10.1016/j.foodres.2010.07.033_bb0245 article-title: Saffron in phytotherapy: Pharmacology and clinical uses publication-title: Wiener Medizinische Wochenschrift doi: 10.1007/s10354-007-0428-4 – volume: 20 start-page: 1 year: 2003 ident: 10.1016/j.foodres.2010.07.033_bb0060 article-title: Growing saffron — The world's most expensive spice publication-title: Crop & Food Research – volume: 10 start-page: 189 year: 1996 ident: 10.1016/j.foodres.2010.07.033_bb0230 article-title: A update review of saffron and its active constituents publication-title: Phytotherapy Research doi: 10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C |
| SSID | ssj0006579 |
| Score | 2.4303186 |
| SecondaryResourceType | review_article |
| Snippet | Saffron (
Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The... Saffron (Crocus sativus, L.) is traditionally used as a coloring or flavoring agent, but recent research has shown its potential to promote health. The... |
| SourceID | proquest pascalfrancis crossref fao elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1981 |
| SubjectTerms | Antioxidant antioxidant activity anxiety Aroma and flavouring agent industries Biological and medical sciences Crocetin Crocin Crocus Crocus sativus Food industries Fundamental and applied biological sciences. Psychology Health health promotion insulin resistance Picrocrocin Saffron Safranal Spice |
| Title | Chemical and biological properties of the world's most expensive spice: Saffron |
| URI | https://dx.doi.org/10.1016/j.foodres.2010.07.033 https://www.proquest.com/docview/1008833379 https://www.proquest.com/docview/1999945146 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1RT9swED6x7mHjYdpgE2Ws8iQkntKG2rEb3hAa6oZgD6USb5ZjxxNoS6qmfeW3c-c4MIQY0h4TxZJ1F999Z3_-DmBfycJmBVaqpbMyESZ1STHxJkHk7Cwicm6DkPb5hZzOxY-r7GoDTrq7MESrjLG_jekhWsc3o2jN0eL6ejRD8I3ZVea0Q02q43SDXSjSzx_ePtA8ZBb19iRP6OuHWzyjm6Gva4dVbWR4qWHK-XP56ZU3NREnTYO2823TiyfxOySl0_fwLqJJdtxO-ANslNUWvOkuGzdbsPmX3uA2_OzkAZipHGv1l8Ljgrbkl6StymrPEBOyoKR60LA_dbNi1AYg8NxZs8DAcsRmxvtlXX2E-em3y5NpEjsqJBYLoVWCxZl33nF0h1SGC26wgPJWyLEqJ2qM2M4eekJ5RTHJHCY1k-UZiQqaNDPoVv4JelVdlTvAhD9UkrR_vExFSTpvmcutpwrEyFwUfRCdHbWNcuPU9eK37nhlNzqaX5P5dao0mr8Pw_thi1Zv46UBk85J-tGPozEnvDR0B52qzS8Mp3o-G9MhLuEjRGl9GDzy9P1cxpxjQudpH752rte4IOmUxVRlvW5IBJoaOHOV_-MbhOW5QKwqd_9_-p_hbaAyBGbhHvRWy3X5BRHSqhiEJTCA18ffz6YXd5bCDW0 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB3xcQAOVUuLWEqpKyFxym5Yf2TTG0JFCwV6WFbiZjl2XIFKstosV357ZxwHiqoWiWMiW7JmnJk38fMbgP1MFVYWWKmWzqpEmNQlxcibBJGzs4jIuQ1C2heXajwVZ9fyegmOu7swRKuMsb-N6SFaxzeDaM3B7OZmMEHwjdlV5fSHmlTHl2FVSJ7R1u4_PPE8lIyCe4onNPzpGs_gtu_r2mFZGyleWT_l_F8JatmbmpiTpkHj-bbrxV8BPGSlk7fwJsJJdtSu-B0sldUmrHW3jZtN2PhDcPA9_Oj0AZipHGsFmMLjjP7Jz0lcldWeIShkQUr1oGF3dbNg1AcgEN1ZM8PI8pVNjPfzuvoA05NvV8fjJLZUSCxWQosEqzPvvOPoD5UZLrjBCspboYZZOcqGCO7soSeYVxQj6TCrGZlLUhU0qTToV74FK1VdldvAhD_MFIn_eJWKkoTepMutpxLEqFwUPRCdHbWNeuPU9uKX7ohltzqaX5P5dZppNH8P-o_TZq3gxksTRp2T9LOdozEpvDR1G52qzU-Mp3o6GdIpLgEkhGk92Hvm6ce1DDnHjM7THnzpXK_xi6RjFlOV9X1DKtDUwRl34n_GIC7PBYJVtfP65X-GtfHVxbk-P738_hHWA68h0Ax3YWUxvy8_IVxaFHvhc_gNucEPAw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chemical+and+biological+properties+of+the+world%27s+most+expensive+spice%3A+Saffron&rft.jtitle=Food+research+international&rft.au=MELNYK%2C+John+P&rft.au=SUNAN+WANG&rft.au=MARCONE%2C+Massimo+F&rft.date=2010-10-01&rft.pub=Elsevier&rft.issn=0963-9969&rft.volume=43&rft.issue=8&rft.spage=1981&rft.epage=1989&rft_id=info:doi/10.1016%2Fj.foodres.2010.07.033&rft.externalDBID=n%2Fa&rft.externalDocID=23328430 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0963-9969&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0963-9969&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0963-9969&client=summon |