Up-Regulation of Cluster of Differentiation (CD) 11b Expression on the Surface of Canine Granulocytes with Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

• Published in: Journal of Veterinary Medical Science Vol. 76; no. 8; pp. 1173 - 1176
• Main Authors: NAKAGAKI, Kazuhide, NUNOMURA, Yuka, UCHIDA, Kanji, NAKATA, Koh, TAZAWA, Ryushi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.08.2014; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; canine; CD11b; CD11b Antigen - metabolism; CHO Cells; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; Escherichia coli - metabolism; flow cytometry; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Granulocytes - metabolism; Humans; Immunology; median fluorescence intensity; xenostimulation; Yeasts - metabolism

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine, sharing a common beta subunit (CDw131) with interleukins 3 and 5. GM-CSF is important for its direct and indirect involvement in host defense. In veterinary medicine, human (h) GM-CSF has been used as a substitute f...