Phenotypic and functional alterations of primary human PBMCs induced by HCV non-enveloped capsid-like particles uptake

• Published in: Cellular and molecular life sciences : CMLS Vol. 70; no. 18; pp. 3463 - 3474
• Main Authors: Doumba, Polyxeni P, Serti, Elisavet, Boutsikou, Maria, Konstadoulakis, Manousos M, Georgopoulou, Urania, Koskinas, John
• Format: Journal Article
• Language: English
• Published: Basel Springer-Verlag 01.09.2013; Springer Basel; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; blood serum; Capsid - metabolism; CD4-positive T-lymphocytes; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - virology; CD8-positive T-lymphocytes; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - virology; Cell Biology; CTLA-4 Antigen - metabolism; Cytokines; Cytokines - metabolism; Gene Expression Regulation; Genotype & phenotype; Hepacivirus - metabolism; Hepatitis; Hepatitis C virus; Humans; Immune response; interferon-gamma; interleukin-10; Interleukin-10 - metabolism; interleukin-2; Interleukin-2 - metabolism; Interleukin-7 Receptor alpha Subunit - metabolism; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - virology; Life Sciences; messenger RNA; patients; Phenotype; Research Article; secretion; T cell receptors; Time Factors; transcriptional activation; transforming growth factor beta; Transforming Growth Factor beta - metabolism; viral proteins; Cytokines; Hepatitis C virus; Tregs; Non-enveloped particles

Hepatitis C virus non-enveloped particles circulate in the serum of HCV-infected patients and are believed to be involved in viral persistence. It was previously demonstrated that recombinant HCVne particles can efficiently enter T cells. In this study we investigated the effect of this entry on the...