Methamphetamine induces apoptosis in immortalized neural cells: Protection by the Proto-Oncogene, bcl-2

• Published in: Synapse (New York, N.Y.) Vol. 25; no. 2; pp. 176 - 184
• Main Authors: Cadet, Jean Lud, Ordonez, Sonia V., Ordonez, Jose V.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.1997
• Subjects: Analysis of Variance; Animals; apoptosis; Apoptosis - drug effects; bcl-2; DNA ladders; dopamine; Flow Cytometry; free radicals; methamphetamine; Methamphetamine - pharmacology; neural cells; neurodegeneration; Neurons - drug effects; Parkinson's disease; Proto-Oncogene Proteins c-bcl-2 - pharmacology; Rats; superoxide

Methamphetamine (METH) is an amphetamine analog that produces degeneration of the dopaminergic system in mammals. The neurotoxic effects of the drug are thought to be mediated by oxygen‐based free radicals. In the present report, we have used immortalized neural cells obtained from rat mesencephalon...