SMARCA4-Deficient Poorly Differentiated Adenocarcinoma of the Gallbladder

A 64-year-old woman presented with chest pain while eating and was referred to our hospital. Physical examination revealed abdominal distension, tenderness, and lower-extremity edema. Imaging revealed a large gallbladder tumor infiltrating the liver, with ascites and pleural effusion. A biopsy confi...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 49; no. 7; p. 688
Main Authors Koyasu, Sho, Sugimoto, Akihiko, Matsubara, Junichi, Muto, Manabu, Nakamoto, Yuji
Format Journal Article
LanguageEnglish
Published United States 01.07.2024
Subjects
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
DNA Helicases - genetics
Female
Gallbladder Neoplasms - diagnostic imaging
Gallbladder Neoplasms - pathology
Humans
Middle Aged
Nuclear Proteins - genetics
Transcription Factors - genetics
Online AccessGet more information
ISSN1536-0229
DOI10.1097/RLU.0000000000005217

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Summary:A 64-year-old woman presented with chest pain while eating and was referred to our hospital. Physical examination revealed abdominal distension, tenderness, and lower-extremity edema. Imaging revealed a large gallbladder tumor infiltrating the liver, with ascites and pleural effusion. A biopsy confirmed a poorly differentiated adenocarcinoma with SMARCA4 deficiency (cT3N2M1, cStage IV). Chemotherapy was ineffective and led to tumor progression. The patient died 9 months later. Recently, attention has been paid to SMARCA4 deficiency, which is a genetic mutation found in tumors. Here, we report on poorly differentiated adenocarcinomas of the gallbladder based on imaging findings, including FDG PET.
ISSN:1536-0229
DOI:10.1097/RLU.0000000000005217