Effects of Polycystic Ovary Syndrome (PCOS), Sex Hormones, and Obesity on Circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 Expression

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 11; pp. E1835 - E1844
• Main Authors: Murri, Mora, Insenser, María, Fernández-Durán, Elena, San-Millán, José L., Escobar-Morreale, Héctor F.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2013; Copyright by The Endocrine Society
• Subjects: Adult; Body mass index; Case-Control Studies; Diabetes mellitus; Female; Gene expression; Gene Expression - physiology; Gonadal Steroid Hormones - blood; Humans; Immune system; Male; Metabolic disorders; Metabolism; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; miRNA; Obesity; Obesity - genetics; Obesity - metabolism; Ovaries; Polycystic ovary syndrome; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Post-transcription; Sex hormones; Young Adult

Context:MicroRNAs (miRNAs) are small, noncoding RNA sequences that negatively regulate gene expression at the post-transcriptional level. miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 have been associated with metabolic disorders such as obesity and diabetes, which are also associated with polycysti...