Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer
Background The 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography (FDG‐PET) has recently become an important non‐invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and progn...
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Published in | Journal of surgical oncology Vol. 100; no. 8; pp. 688 - 692 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15.12.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Background
The 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography (FDG‐PET) has recently become an important non‐invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear.
Method
Seventy‐nine patients with non‐small cell lung cancer (NSCLC) who had undergone preoperative FDG‐PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki‐67 and vascular endothelial growth factor (VEGF) proteins. The relationships between the expression status of these proteins and SUVmax of primary tumors were evaluated.
Result
Concerning the relationship with various clinicopathological findings, SUVmax of primary tumors was associated with histology, tumor proliferation, pleural or vascular invasion, and pathological stage. A significant correlation was observed between the SUVmax and either the Ki‐67 or VEGF expression (P < 0.001, P = 0.006), respectively. Cases with both Ki‐67‐negative and VEGF‐negative findings exhibited a significantly lower SUVmax than those with single positive or double positive cases (P = 0.006, P < 0.001).
Conclusion
The SUVmax was associated with the expression of Ki‐67 and VEGF in NSCLC. These findings indicated that the SUVmax of primary tumors might therefore reflect the biological malignant potential in NSCLC. J. Surg. Oncol. 2009;100:688–692. © 2009 Wiley‐Liss, Inc. |
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Bibliography: | ArticleID:JSO21386 ark:/67375/WNG-ZLQQP1BT-0 istex:806AC059F37925F709CF81294FFF0127B384CC4C ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-4790 1096-9098 |
DOI: | 10.1002/jso.21386 |