DNA rearrangements and phenotypic switching in prokaryotes
Microorganisms have numerous strategies for coping with environmental changes. In many systems, a single cell has the capacity to generate a seemingly infinite array of phenotypic variants in just a few generations of growth. The resulting heterogeneous population is well equipped for sudden environ...
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| Published in | Molecular microbiology Vol. 10; no. 3; p. 465 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
England
01.11.1993
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Microorganisms have numerous strategies for coping with environmental changes. In many systems, a single cell has the capacity to generate a seemingly infinite array of phenotypic variants in just a few generations of growth. The resulting heterogeneous population is well equipped for sudden environmental change; even if only a few cells in the population possess a phenotype needed for survival, these cells have the capacity to regenerate a similarly diverse population. Phenotypic switching in these systems usually results from high-frequency DNA rearrangements which are the subject of this review. |
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| AbstractList | Microorganisms have numerous strategies for coping with environmental changes. In many systems, a single cell has the capacity to generate a seemingly infinite array of phenotypic variants in just a few generations of growth. The resulting heterogeneous population is well equipped for sudden environmental change; even if only a few cells in the population possess a phenotype needed for survival, these cells have the capacity to regenerate a similarly diverse population. Phenotypic switching in these systems usually results from high-frequency DNA rearrangements which are the subject of this review. |
| Author | Dybvig, K |
| Author_xml | – sequence: 1 givenname: K surname: Dybvig fullname: Dybvig, K organization: Department of Comparative Medicine, University of Alabama at Birmingham 35294 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7968525$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Chromosome Inversion DNA Nucleotidyltransferases - metabolism DNA, Bacterial - genetics DNA, Viral - genetics Endonucleases - metabolism Gene Conversion Gene Expression Regulation Gene Rearrangement Integrases Phenotype Prokaryotic Cells - cytology Prokaryotic Cells - metabolism Recombinases Recombination, Genetic Repetitive Sequences, Nucleic Acid |
| Title | DNA rearrangements and phenotypic switching in prokaryotes |
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