Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase - Salloum, Shadi; Jeyarajan, Andre J; Kruger, Annie J; Holmes, Jacinta A; Shao, Tuo; Sojoodi, Mozhdeh; Kim, Myung-Ho; Zhuo, Zhu; Shroff, Stuti G; Kassa, Andrew; Corey, Kathleen E; Khan, Sanjoy K; et al. (Cellular and molecular gastroenterology and hepatology, 2021)
Keywords: Animals; Biomarkers; Computational Biology - methods; Disease Models, Animal; Disease Progression; Disease Susceptibility; Fatty Acids - metabolism; Female; Fibrosis; Gastroenterology and Hepatology; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes - metabolism; Humans; Immunohistochemistry; Liver Cirrhosis - etiology; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Function Tests; Male; Mice; Models, Biological; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Nonalcoholic Fatty Liver Disease; Original Research; p38 MAPK; p38 Mitogen-Activated Protein Kinases - metabolism; YAP; YAP-Signaling Proteins - metabolism; FFA; extracellular signal-regulated kinase; JNK; small interfering RNA; high fat diet; nonalcoholic steatohepatitis; α-SMA; shRNA; short hairpin RNA; pHSC; hepatocellular carcinoma; c-Jun N-terminal kinase; IL; HCC; MAPK; p38 MAPK; green fluorescent protein; choline-deficient; simple steatosis; Massachusetts General Hospital; Fibrosis; CDAHFD; primary human hepatocyte; ERK; α-smooth muscle actin; NAFLD; NT; YAP; mRNA; GFP; mitogen-activated protein kinase; PHH; messenger RNA; interleukin; WT; knockout; lipid droplet; RNA sequencing; SS; KO; siRNA; NASH; RNAseq; ECM; MGH; L-amino acid defined; nontargeting; free fatty acid; Nonalcoholic Fatty Liver Disease; LD; wild-type; extracellular matrix; primary human hepatic stellate cell