An Isolated Cardiac Conduction Disease Maps to Chromosome 19q

• Published in: Circulation research Vol. 77; no. 4; pp. 735 - 740
• Main Authors: de Meeus, Anne, Stephan, Edouard, Debrus, Sophie, Jean, Marie-Kamala, Loiselet, Jacques, Weissenbach, Jean, Demaille, Jacques, Bouvagnet, Patrice
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.10.1995; Lippincott; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Base Sequence; Biological and medical sciences; Biomarkers; Cardiology. Vascular system; Chromosome Mapping; Chromosomes, Human, Pair 19 - genetics; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Death, Sudden, Cardiac; Family; Genetic Linkage; Heart; Heart Block - genetics; Heart Conduction System - physiopathology; Humans; Medical sciences; Molecular Sequence Data; Genetic mapping; Heart; Human; Chromosome 19; Genetic inheritance; Arrhythmia; Genetic marker; Sudden death; Cardiovascular disease; Conduction disorder; Genetic disease; Heart disease; Autosomal character; Localization

Isolated cardiac conduction disease is an autosomal dominant defect that includes various combinations of bundle branch or fascicular blocks. These defects can cause sudden death due to a complete heart block. We used a genome-wide screening approach with polymorphic (CA)n repeat markers to determin...