Eosinophils and eosinophil cationic protein in nasal lavages in allergen-induced hyperresponsiveness: effects of topical glucocorticosteroid treatment

• Published in: Allergy (Copenhagen) Vol. 44; no. 5; p. 342
• Main Authors: Andersson, M, Andersson, P, Venge, P, Pipkorn, U
• Format: Journal Article
• Language: English
• Published: Denmark 01.07.1989
• Subjects: Administration, Topical; Adult; Anti-Inflammatory Agents - therapeutic use; Blood Proteins - metabolism; Budesonide; Clinical Trials as Topic; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils - metabolism; Female; Glucocorticoids; Humans; Male; Nasal Mucosa - drug effects; Nasal Mucosa - metabolism; Pregnenediones - therapeutic use; Random Allocation; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Perennial - metabolism; Ribonucleases; Therapeutic Irrigation

Airway challenges with allergen are frequently followed by an increase in responsiveness to both specific and unspecific stimuli. This phenomenon in the lower airways has been linked to the presence of a late phase response to allergen challenge. One of the hallmarks of the late phase response is a...